Difference between revisions of "Gastrointestinal tract polyps"

Gastrointestinal tract polyps (view source)

813 bytes added , 05:15, 14 December 2011

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 *Serrated epithelial cells (at the surface of the gland) - only colorectal polyps - '''key feature'''.
 **''Serrated'' appearance = ''saw-tooth'' appearance, epithelium has jagged edge.
+Notes:
 *Significant negatives:
 **No nuclear atypia.
-**Goblet cells should be present (as is usual in the colon).
+**In the colon goblet cells should be present (as is usual).
 DDx:
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 *[http://commons.wikimedia.org/wiki/File:Hyperplastic_polyp1.jpg HP - high mag. (WC)].
 *[http://commons.wikimedia.org/wiki/File:Hyperplastic_polyp2.jpg HP - lower mag. (WC)].
+====Subclassification====
+*Usually '''not subclassified''' as there is no demonstrated prognostic significance;<ref name=pmid21045813/> the subtyping is an academic exercise.
+HPs may be subclassified into two groups:<ref name=pmid21045813/>
+#Microvesicular serrated polyps (MVSPs).
+#Goblet cell serrated polyps (GCSPs).
+Features of the HP subtypes:<ref name=pmid21045813/>
+{| class="wikitable sortable"
+| '''Subtype'''
+| '''Histology'''
+| '''Mutations'''
+| '''Precursor lesion'''
+|-
+| Microvesicular
+| microvesicles at the surface, serration<br> at the surface to the mid portion of glands
+| BRAF V600E, CIMP
+| precursor to [[sessile serrated adenoma]] (?)
+|-
+| Goblet cell
+| superficial goblet cells, serration at <br>the surface
+| KRAS
+| unknown
+|}
+Notes:
+*CIMP = CpG island methylation phenotype.
 =Inflammatory pseudopolyp=