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Difference between revisions of "Thymus"
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'''Thymus''' is an annoying little organ that is in the mediastinum. | '''Thymus''' is an annoying little organ that is in the [[mediastinum]]. It is often removed in pediatric cardiac surgery 'cause it is in the way. In adults, it is commonly removed 'cause the patient has myasthenia gravis. | ||
=Overview= | =Overview= | ||
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*Important for development of the immune system. | *Important for development of the immune system. | ||
*May contain within it parathyroid.<ref name=Ref_PBoD706>{{Ref PBoD|706}}</ref> | *May contain within it parathyroid.<ref name=Ref_PBoD706>{{Ref PBoD|706}}</ref> | ||
*May be absent due to genetic abnormalities, e.g. Di George syndrome. | |||
==Normal histology== | ==Normal histology== | ||
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*[[Thyroid]] (ectopic). | *[[Thyroid]] (ectopic). | ||
=Thymus and stress= | ==Thymus and stress== | ||
*Stress -> increased endogenous steroid -> lymphocyte death -> increased tingible body macrophages.<ref>{{cite journal |author=Toti P, De Felice C, Stumpo M, ''et al.'' |title=Acute thymic involution in fetuses and neonates with chorioamnionitis |journal=Hum. Pathol. |volume=31 |issue=9 |pages=1121–8 |year=2000 |month=September |pmid=11014581 |doi= |url=}}</ref> | *Stress -> increased endogenous steroid -> lymphocyte death -> increased tingible body macrophages.<ref>{{cite journal |author=Toti P, De Felice C, Stumpo M, ''et al.'' |title=Acute thymic involution in fetuses and neonates with chorioamnionitis |journal=Hum. Pathol. |volume=31 |issue=9 |pages=1121–8 |year=2000 |month=September |pmid=11014581 |doi= |url=}}</ref> | ||