Renal cell carcinoma with rhabdoid morphology
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Renal cell carcinoma with rhabdoid morphology is an uncommon finding with a poor prognosis. It is also known as renal cell carcinoma with rhabdoid change.
It should not be confused with renal rhabdoid tumour.
General
- Not recognized as a distinct entity.[1]
- ISUP nucleolar grade 4 by definition.
- May be seen in ALK translocation renal cell carcinoma.[2]
Microscopic
Features:
- Rhabdoid cells:
- Eccentrically placed large round nuclei with abundant eosinophilic cytoplasm.
- +/-Very prominent nucleolus.
Notes:
- May be multinucleated.
Images
IHC
Features:[3]
- Vimentin +ve (23 of 23 cases).
- NSE +ve (~80% of cases).
- S-100 -ve/+ve (+ve ~ 40% of cases).
- Desmin -ve (23 of 23 cases).
- SMA -ve (~5% of cases).
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MASS, RIGHT KIDNEY, RADICAL NEPHRECTOMY: - CLEAR CELL RENAL CELL CARCINOMA, ISUP NUCLEOLAR GRADE 4, pT1b, pNX. -- RHABDOID CHANGE PRESENT, SEE COMMENT. -- MARGINS NEGATIVE FOR MALIGNANCY. -- PLEASE SEE TUMOUR SUMMARY. COMMENT: Rhabdoid change is considered by some to be analogous to sarcomatoid change.[1] The rhabdoid change in this case represents approximately 35% of the tumour, and has ISUP nucleolar grade 4 nuclear features. 1. Ann Diagn Pathol. 2011 Oct;15(5):333-7.
See also
- Renal cell carcinoma.
- Renal cell carcinoma with sarcomatoid differentiation.
- Rhabdoid.
- ISUP nucleolar grade.
References
- ↑ Chapman-Fredricks, JR.; Herrera, L.; Bracho, J.; Gomez-Fernandez, C.; Leveillee, R.; Rey, L.; Jorda, M. (Oct 2011). "Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma.". Ann Diagn Pathol 15 (5): 333-7. doi:10.1016/j.anndiagpath.2011.03.002. PMID 21665507.
- ↑ Kuroda, N.; Karashima, T.; Inoue, K.; Kasajima, A.; Ohe, C.; Kawakami, F.; Mikami, S.; Matsuura, K. et al. (Mar 2015). "Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects.". Pol J Pathol 66 (1): 3-8. PMID 26017874.
- ↑ Gökden, N.; Nappi, O.; Swanson, PE.; Pfeifer, JD.; Vollmer, RT.; Wick, MR.; Humphrey, PA. (Oct 2000). "Renal cell carcinoma with rhabdoid features.". Am J Surg Pathol 24 (10): 1329-38. PMID 11023094.