Renal oncocytosis
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| Renal oncocytosis | |
|---|---|
| Diagnosis in short | |
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| |
| LM | any mixture of oncocytic tumours - see hybrid tumour, chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma; "in situ" oncocytic cells (outside of the tumour) |
| LM DDx | other renal tumours with eosinophilic cytoplasm |
| IHC | characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour |
| Molecular | +/-gain of chromosome 5, do not typically have chromosomal losses seen in ChRCC |
| Gross | multiple brown kidney nodules (bilateral or unilateral) |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | Birt–Hogg–Dubé syndrome |
|
| |
| Clinical history | +/-chronic renal failure and hemodialysis |
| Prevalence | rare |
| Radiology | multiple renal tumours (unilateral or bilateral) |
| Clin. DDx | metastatic disease, multifocal renal cell carcinoma |
Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]
General
- Rare.
- May be seen in the context of Birt–Hogg–Dubé syndrome or chronic renal failure or may be sporadic.[1]
- Chronic renal failure seen in 50% of cases in one series.[2]
Gross
- Multiple (unilateral or bilateral) brown-coloured nodules.[1]
Microscopic
Features:
- Any mixture of oncocytic tumours (hybrid tumour, chromophobe renal cell carcinoma, renal oncocytoma).
- "In situ" oncocytic cells (similar to the tumour cells) within renal tubules.[3]
DDx:
- Hybrid tumour.
- Chromophobe renal cell carcinoma.
- Renal oncocytoma.
- Other renal tumours with eosinophilic cytoplasm.
Images
IHC
- Characteristic of the histologic appearance.[1]
- Stain like renal oncocytomas, chromophobe renal cell carcinomas and hybrid tumours.
Molecular
- Scant data suggests chromosomal changes are seen that are different than those of ChRCC and oncocytoma.[4]
- Do not have the chromosomal losses typical of ChRCC.
- May have gains in chromosome 5.
Note:
- ChRCC typically has loss of chromosomes: 1, 2, 6, 10, 13, 17, 21.[5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
- ↑ Adamy, A.; Lowrance, WT.; Yee, DS.; Chong, KT.; Bernstein, M.; Tickoo, SK.; Coleman, JA.; Russo, P. (Mar 2011). "Renal oncocytosis: management and clinical outcomes.". J Urol 185 (3): 795-801. doi:10.1016/j.juro.2010.10.068. PMID 21239013.
- ↑ 3.0 3.1 Huang, J.; Lee, P.; Mikami, Y.; Melamed, J. (2009). "Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis).". Int J Clin Exp Pathol 2 (6): 583-7. PMID 19636405.
- ↑ Gobbo, S.; Eble, JN.; Delahunt, B.; Grignon, DJ.; Samaratunga, H.; Martignoni, G.; Zhang, S.; Wang, M. et al. (May 2010). "Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles.". Am J Surg Pathol 34 (5): 620-6. doi:10.1097/PAS.0b013e3181d73293. PMID 20305535.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.