Renal oncocytosis

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Renal oncocytosis
Diagnosis in short

LM any mixture of oncocytic tumours - see hybrid tumour, chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma; "in situ" oncocytic cells (outside of the tumour)
LM DDx other renal tumours with eosinophilic cytoplasm
IHC characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour
Molecular +/-gain of chromosome 5, do not typically have chromosomal losses seen in ChRCC
Gross multiple brown kidney nodules (bilateral or unilateral)
Grossing notes total nephrectomy for tumour grossing, partial nephrectomy grossing
Staging kidney cancer staging
Site kidney - see kidney tumours

Syndromes Birt–Hogg–Dubé syndrome

Clinical history +/-chronic renal failure and hemodialysis
Prevalence rare
Radiology multiple renal tumours (unilateral or bilateral)
Clin. DDx metastatic disease, multifocal renal cell carcinoma

Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]



  • Multiple (unilateral or bilateral) brown-coloured nodules.[1]







  • Scant data suggests chromosomal changes are seen that are different than those of ChRCC and oncocytoma.[4]
    • Do not have the chromosomal losses typical of ChRCC.
    • May have gains in chromosome 5.


  • ChRCC typically has loss of chromosomes: 1, 2, 6, 10, 13, 17, 21.[5]

See also


  1. 1.0 1.1 1.2 1.3 Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
  2. Adamy, A.; Lowrance, WT.; Yee, DS.; Chong, KT.; Bernstein, M.; Tickoo, SK.; Coleman, JA.; Russo, P. (Mar 2011). "Renal oncocytosis: management and clinical outcomes.". J Urol 185 (3): 795-801. doi:10.1016/j.juro.2010.10.068. PMID 21239013.
  3. 3.0 3.1 Huang, J.; Lee, P.; Mikami, Y.; Melamed, J. (2009). "Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis).". Int J Clin Exp Pathol 2 (6): 583-7. PMID 19636405.
  4. Gobbo, S.; Eble, JN.; Delahunt, B.; Grignon, DJ.; Samaratunga, H.; Martignoni, G.; Zhang, S.; Wang, M. et al. (May 2010). "Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles.". Am J Surg Pathol 34 (5): 620-6. doi:10.1097/PAS.0b013e3181d73293. PMID 20305535.
  5. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.