Prostate cancer with neuroendocrine differentiation

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Prostate cancer with neuroendocrine differentiation is a rare group of prostate cancers that is hypothesized to evolve in the context androgen deprivation therapy.[1]

Neuroendocrine carcinoma of the prostate redirect here.


  • Treatment: platinum based therapy.


It is subclassified as per Epstein et al.:[1]

  • Usual prostate adenocarcinoma with neuroendocrine differentiation.
  • Adenocarcinoma with Paneth cell neuroendocrine differentiation.
  • Carcinoid tumour of the prostate.
  • Small cell carcinoma of the prostate gland.
  • Large cell neuroendocrine carcinoma of the prostate.
  • Mixed (small and/or large cell) neuroendocrine carcinoma-acinar adenocarcinoma.


  • PSA typically negative in neuroendocrine carcinomas.

See also


  1. 1.0 1.1 Epstein, JI.; Amin, MB.; Beltran, H.; Lotan, TL.; Mosquera, JM.; Reuter, VE.; Robinson, BD.; Troncoso, P. et al. (Jun 2014). "Proposed morphologic classification of prostate cancer with neuroendocrine differentiation.". Am J Surg Pathol 38 (6): 756-67. doi:10.1097/PAS.0000000000000208. PMID 24705311.