Progressive transformation of germinal centers

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Progressive transformation of germinal centers
Diagnosis in short

PTGC. H&E stain.

LM follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone
LM DDx nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas
Site lymph node

Signs lymphadenopathy
Symptoms asymptomatic
Prevalence very rare
Clin. DDx lymph node metastasis, lymphoma

Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.

General

Clinical:

  • Asymptomatic lymphadenopathy.

Microscopic

Features:

  • Follicular hyperplasia (many follicles).
  • Focally large germinal centers with:
    • Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
    • Expanded mantle zone.

Images

See also

References

  1. 1.0 1.1 Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC (2002). "Progressive transformation of germinal centers. Report of 2 cases and review of the literature". Acta Haematol. 108 (1): 33–8. PMID 12145465.

Additional reading

  • Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
  • Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.