Clear cell adenocarcinoma of the urethra
(Redirected from Primary urethral clear cell adenocarcinoma)
Jump to navigation
Jump to search
Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.
General
- Predominantly in women.[1]
Pathogenesis not well understood - may arise from:
- Muellerian rests or urothelium.[1]
- Shed kidney cells.[2]
- Nephrogenic adenoma - malignant transformation.[1]
Microscopic
Features:[1]
- Clear cells (at least focally).
- Columnar or cuboidal morphology.
- At least moderate nuclear pleomorphism.[2]
- Hobnailing (classic feature).
Note:
- Described as morphologically similar to clear cell adenocarcinoma of the gynecologic tract[2] - see clear cell carcinoma of the uterine cervix.
DDx:
- Nephrogenic adenoma[2][3] - also has hobnailing, not mitotically active, no necrosis, no or mild nuclear atypia.
- Clear cell renal cell carcinoma.
- Clear cell adenocarcinoma of the gynecologic tract.
- Other clear cell tumours.
Images
www:
IHC
Features:[2]
- PAX8 +ve/-ve (2 +ve in 4 cases).
- CK7 +ve/-ve (2 +ve in 4 cases).
- Vimentin +ve (3 +ve in 4 cases).
- CK20 -ve/+ve (1 +ve in 4 cases).
Others:[2]
- ER -ve.
- p63 -ve.
- PSA -ve.
- p16 -ve.
- Ki-67 ~ 47/200 on average cells.
- 5.5/200 cells on average in nephrogenic adenoma.[5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.
- ↑ Brimo, F.; Herawi, M.; Sharma, R.; Netto, GJ.; Epstein, JI.; Illei, PB. (Nov 2011). "Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis.". Hum Pathol 42 (11): 1613-9. doi:10.1016/j.humpath.2011.01.007. PMID 21496868.
- ↑ Han, JY.; Kim, KH.; Kim, L.; Choi, SJ.; Park, IS.; Kim, JM.; Chu, YC.; Yoon, SM. (Apr 2012). "Cytologic findings of clear cell adenocarcinoma of the urethra: a case report.". Korean J Pathol 46 (2): 210-4. doi:10.4132/KoreanJPathol.2012.46.2.210. PMID 23110004.
- ↑ Gilcrease, MZ.; Delgado, R.; Vuitch, F.; Albores-Saavedra, J. (Dec 1998). "Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.". Hum Pathol 29 (12): 1451-6. PMID 9865832.