Polar Spongioblastoma

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Polar Spongioblastoma is a depreceated tumour entity. It was categorized in the WHO 1993 and WHO 1997 classfication as neuroepithelial tumour of uncertain origin without assigning a WHO grade (ICD-O code 9423/3). The tumour was removed as distinct entity in the WHO 2000 classification.

In the first description in 1948 the tumour was characterized by bipolar tumor cells with palisading nuclei. There was a long standing controversy, whether the tumour was a morphologically a distinct entity or merely a occasionally observed growth pattern in conventional giomas, especially ependymomas or oligodendrogliomas. [1][2][3] The growth pattern and molecular profile is discussed in single case reports.[4][5]


Exemplary image in [ pubcan.org [1]]

See also


  1. Schiffer, D.; Cravioto, H.; Giordana, MT.; Migheli, A.; Pezzulo, T.; Vigliani, MC. (Apr 1993). "Is polar spongioblastoma a tumor entity?". J Neurosurg 78 (4): 587-91. doi:10.3171/jns.1993.78.4.0587. PMID 8450332.
  2. Jansen, GH.; Troost, D.; Dingemans, KP. (1990). "Polar spongioblastoma: an immunohistochemical and electron microscopical study.". Acta Neuropathol 81 (2): 228-32. PMID 1707207.
  3. Langford, LA.; Camel, MH. (1987). "Palisading pattern in cerebral neuroblastoma mimicking the primitive polar spongioblastoma. An ultrastructural study.". Acta Neuropathol 73 (2): 153-9. PMID 3604582.
  4. Fukushima, S.; Narita, Y.; Shinomiya, A.; Ohno, M.; Miyakita, Y.; Okita, Y.; Hanakawa, K.; Ide, T. et al. (Dec 2012). "A case of unclassified high-grade glioma with polar spongioblastoma pattern.". Neuropathology 32 (6): 604-10. doi:10.1111/j.1440-1789.2012.01303.x. PMID 22393945.
  5. Nagaishi, M.; Tanaka, Y.; Iwatate, K.; Yokoo, H.; Ueki, K.; Hyodo, A.; Nakazato, Y. (Oct 2010). "Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH.". Neuropathology 30 (5): 547-52. doi:10.1111/j.1440-1789.2009.01087.x. PMID 20102524.