Pit1

From Libre Pathology
Jump to navigation Jump to search
Pit1
Immunostain in short
Abbreviation Pit1
Normal staining pattern nuclear staining
Positive Somatotroph, lactotroph adenoma


POU domain, class 1, transcription factor 1 (growth hormone factor 1), also known as POU1F1, abbreviated Pit1, is a immunostain used endocrinology.

General

  • Nuclear stain.


Positive

Pit-1 lineage pituitary tumors:[1]

  • Somatotroph adenoma.
  • Lactotroph adenoma.
  • Thyreotropha adenoma.
  • Mammary gland.[2]


Occasionally positive

Negative

  • Corticotroph adenoma.
  • Gonadotroph adenoma.
  • Null cell adenoma.

See also

Wikipedia page: [1]

References

  1. Lloyd, RV.; Osamura, RY. (Oct 1997). "Transcription factors in normal and neoplastic pituitary tissues.". Microsc Res Tech 39 (2): 168-81. doi:10.1002/(SICI)1097-0029(19971015)39:2<168::AID-JEMT8>3.0.CO;2-H. PMID 9361268.
  2. Sendon-Lago, J.; Seoane, S.; Eiro, N.; Bermudez, MA.; Macia, M.; Garcia-Caballero, T.; Vizoso, FJ.; Perez-Fernandez, R. (Dec 2014). "Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.". Breast Cancer Res 16 (6): 505. doi:10.1186/s13058-014-0505-8. PMID 25527274.