Progressive transformation of germinal centers
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|Progressive transformation of germinal centers|
|Diagnosis in short|
PTGC. H&E stain.
|LM||follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone|
|LM DDx||nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas|
|Clin. DDx||lymph node metastasis, lymphoma|
Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.
- Asymptomatic lymphadenopathy.
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.
- Expanded mantle zone.
- Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
- Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.