From Libre Pathology
(Redirected from Nuclear-to-cytoplasmic ratio)
Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.
NC ratio is a better predictor of malignancy than increased nuclear size.
High NC ratio in normal cells
Low NC ratio in cancer
High NC ratio in cancer
- Many other tumours - see A long differential diagnosis of small blue cell tumours.
- Preoperative treatment may increase NC ratio - example: pituitary adenoma under bromocriptine treatment.
Atypical cells with a normal NC ratio
- Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.
- Nissim, M.; Ambrosi, B.; Bernasconi, V.; Giannattasio, G.; Giovanelli, MA.; Bassetti, M.; Vaccari, U.; Moriondo, P. et al. "Bromocriptine treatment of macroprolactinomas: studies on the time course of tumor shrinkage and morphology.". J Endocrinol Invest 5 (6): 409-15. doi:10.1007/BF03350542. PMID 7169515.