Nodular hidradenoma

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Nodular hidradenoma, also known as eccrine acrospiroma,[1] is a benign adnexal skin tumour.


  • Benign adnexal tumour.[2]


Typical locations:[1]

  • Scalp.
  • Face.
  • Trunk, anterior.



  • Well-circumscribed dermal lesions with:
    • Back-to-back nests with a whorled appearance.
    • Spaces between cells.
    • Nuclei ovoid and centrally placed in the cell.
      • No nucleolus.
    • Cystic spaces with degenerated cells.





  • CAM5.2 +ve.
  • AE1/AE3 +ve.
  • EMA +ve.
  • S100 -ve.
  • Desmin -ve.

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Left Thumb Lesion, Excision:
     - Hidradenoma.


The sections show an epithelial tumour with squamoid features, mild pleomorphism and whirling, that underlies a benign epidermis. Degenerative changes are present. Rare mitotic figures are seen.

PAS and PASD staining shows PAS-positive diastase-resistant droplets. The tumour is CAM5.2 POSITIVE, S-100 NEGATIVE and SMA NEGATIVE.

See also


  1. 1.0 1.1 Punia, RP.; Garg, S.; Bal, A.; Mohan, H. (2008). "Pigmented nodular hidradenoma masquerading as nodular malignant melanoma.". Dermatol Online J 14 (1): 15. PMID 18319032.
  2. 2.0 2.1 2.2 Stratigos, AJ.; Olbricht, S.; Kwan, TH.; Bowers, KE. (Mar 1998). "Nodular hidradenoma. A report of three cases and review of the literature.". Dermatol Surg 24 (3): 387-91. PMID 9537017.
  3. Nakazato S, Yanagi T, Inamura Y, Kitamura S, Hata H, Shimizu H (August 2016). "A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma". Eur J Dermatol 26 (4): 409–10. doi:10.1684/ejd.2016.2810. PMID 27350422.