Neuroendocrine markers

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Neuroendocrine markers are immunostains that suggest neuroendocrine differentiation.

Common markers

  • Chromogranin A.
    • Considered the most specific neuroendocrine stain.[1]
  • Synaptophysin +ve.
  • CD56.
    • Less specific than chromogranin A and synaptophysin.

Less common markers

See also


  1. McCluggage, WG.; Kennedy, K.; Busam, KJ. (Apr 2010). "An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63.". Am J Surg Pathol 34 (4): 525-32. doi:10.1097/PAS.0b013e3181d1d457. PMID 20182342.