Negative prostatectomy

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Vanishing prostate cancer redirects here.

Negative prostatectomy, also radical prostatectomy without cancer, occasionally happens.


  • Seen in approximately 1% of prostatectomies.[1]


  1. Review biopsy if available.
    • Is it plausible?
      • Biopsies in negative prostatectomies or minimal cancer prostatectomies usually have a small volume of low grade cancer.
      • A negative prostatectomy with high-grade cancer on biopsy or a large volume of disease on biopsy should prompt identity testing.[2]
  2. Submit prostate in total (if not already done).
  3. Levels (x3) on all prostate blocks.[1]
  4. Flip the (prostate tissue) blocks and do levels (x3).[1]

See also


  1. 1.0 1.1 1.2 Kosarac, O.; Zhai, QJ.; Shen, S.; Takei, H.; Ro, JY.; Ayala, AG. (Nov 2011). "Minimal or no residual prostatic adenocarcinoma on radical prostatectomy: a 5-year experience with vanishing carcinoma phenomenon.". Arch Pathol Lab Med 135 (11): 1466-70. doi:10.5858/arpa.2010-0132-OA. PMID 22032574.
  2. Cao, D.; Hafez, M.; Berg, K.; Murphy, K.; Epstein, JI. (Apr 2005). "Little or no residual prostate cancer at radical prostatectomy: vanishing cancer or switched specimen?: a microsatellite analysis of specimen identity.". Am J Surg Pathol 29 (4): 467-73. PMID 15767799.