|Diagnosis in short|
Myxomatous valve. Movat stain. (WC)
|LM||thinning of fibrosa layer, thickening of spongiosa layer with mucoid (myxomatous) material, +/-secondary changes due to valvular dysfunction (e.g. thrombi, fibrosis)|
|Stains||Movat stain - to demonstrate mucoid material|
|Gross||valve thickened, rubbery consistency, reactive/secondary changes common (fibrosis due to prolapse/abnormal contact of valve with other structures, clots/organized thrombus due to stasis)|
|Grossing notes||Mitral valve grossing|
|Site||heart valve, typical mitral valve|
|Syndromes||Marfan's syndrome, Turner syndrome|
Myxomatous degeneration of heart valves is rare benign condition that is typically seen in the mitral valve, and may be associated with various genetic conditions.
- Usually affects the mitral valve.
- Female > male, disputed by Toronto data.
- Associated with Marfan's syndrome and Turner syndrome (Monosomy X).
- No commissural fusion.
- Commissural fusion typical of rheumatic heart disease.
- Rubbery consistency.
- Reactive/secondary changes.
- Fibrosis due to prolapse/abnormal contact of valve with other structures.
- Clots/organized thrombus - due to stasis.
- Thinning of fibrosa layer.
- Thickening of spongiosa layer with mucoid (myxomatous) material. (key feature).
- +/-Secondary changes (due to valvular dysfunction): thrombi, fibrosis.
- Movat stain.
Interpretation of Movat stain:
- Black = nuclei and elastic fibers.
- Yellow = collagen and reticular fibers.
- Blue = mucin, ground substance.
- Red (intense) = fibrin.
- Red = muscle.
Myxomatous valve. Movat stain. (WC/Nephron)
- URL: http://emedicine.medscape.com/article/759004-overview. Accessed on: 8 June 2010.
- Leong SW, Soor GS, Butany J, Henry J, Thangaroopan M, Leask RL (October 2006). "Morphological findings in 192 surgically excised native mitral valves". Can J Cardiol 22 (12): 1055-61. PMID 17036100.
- Wigle ED, Rakowski H, Ranganathan N, Silver MC (1976). "Mitral valve prolapse". Annu. Rev. Med. 27: 165–80. doi:10.1146/annurev.me.27.020176.001121. PMID 779595.
- Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 591. ISBN 0-7216-0187-1.
- URL: http://www.mayomedicallaboratories.com/test-catalog/Overview/9832. Accessed on: 8 June 2010.
- Modified Movat's Pentachrome Stain. University Penn Medicine. URL: http://www.med.upenn.edu/mcrc/histology_core/movat.shtml. Accessed on: January 29, 2009.