Mucinous adenocarcinoma of the prostate

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Mucinous adenocarcinoma of the prostate
Diagnosis in short

Mucinous adenocarcinoma of the prostate (left of image) with acinar adenocarcinoma of the prostate (right of image). H&E stain. (WC/Nephron)

LM cytologically malignant (prostatic) cells floating in mucin; >25% of tumour mucinous
LM DDx acinar adenocarcinoma of the prostate with a minor mucinous component (<25%), metastatic mucinous carcinoma, mucinous adenocarcinoma of the prostatic urethra
Grossing notes prostatectomy grossing, TURP specimens
Site prostate gland - see prostate cancer

Prevalence rare
Blood work PSA elevated
Prognosis dependent on grade
Treatment prostatectomy, radiation or observation

Mucinous adenocarcinoma of the prostate is an uncommon type of prostate cancer.

General

  • Rare.[1]
  • Most often Gleason 3+4 ~ 80% in one series of 47 cases.[1]

Gleason pattern:

  • In the past, it has been suggested that the mucinous component be assigned Gleason pattern 4.[2]
  • The prognosis is similar or may be better than the conventional type of prostate cancer in a large series;[1] thus, it seems reasonable to grade based on the pattern (as advocated by some experts[3]).

Microscopic

Features:

  • Cytologically malignant cells floating in mucin.
  • > 25% of tumour mucinous.[2]
    • Two studies suggests >= 25%.[4][5]

Notes:

DDx:

Images

See also

References

  1. 1.0 1.1 1.2 Osunkoya, AO.; Nielsen, ME.; Epstein, JI. (Mar 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.". Am J Surg Pathol 32 (3): 468-72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
  2. 2.0 2.1 Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
  3. Osunkoya, AO.; Adsay, NV.; Cohen, C.; Epstein, JI.; Smith, SL. (Jul 2008). "MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomy.". Mod Pathol 21 (7): 789-94. doi:10.1038/modpathol.2008.47. PMID 18487999.
  4. Osunkoya AO, Nielsen ME, Epstein JI (March 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases". Am. J. Surg. Pathol. 32 (3): 468–72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
  5. 5.0 5.1 Bohman, KD.; Osunkoya, AO. (Nov 2012). "Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.". Adv Anat Pathol 19 (6): 374-87. doi:10.1097/PAP.0b013e318271a361. PMID 23060063.