Keratins

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In pathology, keratins, also cytokeratins, refers to a set of immunostains that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells (carcinomas).

Keratin when used in singular may refer to pankeratin.

Classification

Divided by molecular weight:[1]

  • Low molecular weight keratins (LMWK): 7, 8/18, 19, 20.
  • High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.

Uses

Sarcomas and keratins

  • Most sarcomas are cytokeratin negative.

Classic exceptions:

Others:

See also

References

  1. http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm
  2. Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H (September 1993). "The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma". Pathol. Res. Pract. 189 (8): 888–93. PMID 7508102.
  3. URL: http://www.aruplab.com/guides/ug/tests/2003978.jsp. Accessed on: 17 March 2011.