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Diagnosis in short

Hibernoma. H&E stain.

LM large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular
LM DDx reaction to silicone implant
Gross lobulated lesion, light-brown, usually extremities
Site cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see soft tissue - adipocytic lesions

Clinical history typically young adults
Prevalence uncommon
Prognosis benign
Clin. DDx Lipoma

Hibernoma, also tumour of brown fat,[1] is an uncommon adipocytic tumour.


  • Consists of brown fat (present in the infants to generate heat).[2]
  • Benign.
  • Usually asymptomatic.[3]


  • Young adults - disappears with age.[4]


  • Well-circumscribed.
  • Lobulated and light-brown on sectioning.


  • Cervical-supraclavicular.
  • Periaortic - both thorax and the abdomen.
  • Perirenal.



  • Large polygonal/oval cells:
    • Nucleus - central & small.[6]
      • Nucleoli typically prominent.[7]
    • Cytoplasm - multivacuolated, oval, eosinophilic, granular.
  • +/-Prominent blood vessels, central.[8]


  • Reaction to silicone implant.


See also


  1. SHUTE, D. (Nov 1954). "Tumours of brown fat.". Can Med Assoc J 71 (5): 484-5. PMID 13209434.
  2. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 605. ISBN 978-0781765275.
  3. Ahmed SA, Schuller I (December 2008). "Pediatric hibernoma: a case review". J. Pediatr. Hematol. Oncol. 30 (12): 900–1. doi:10.1097/MPH.0b013e318184e6dd. PMID 19131775.
  4. 4.0 4.1 Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M (2019). "Brown and Beige Adipose Tissue and Aging". Front Endocrinol (Lausanne) 10: 368. doi:10.3389/fendo.2019.00368. PMC 6595248. PMID 31281288. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595248/.
  5. Chen DY, Wang CM, Chan HL (March 1998). "Hibernoma. Case report and literature review". Dermatol Surg 24 (3): 393–5. PMID 9537018.
  6. http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6
  7. http://surgpathcriteria.stanford.edu/softfat/hibernoma/
  8. URL: http://radiographics.rsna.org/content/24/5/1433.full. Accessed on: 11 February 2013.