Haematopoiesis
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Haematopoiesis is the making of blood. Problems in haematopoiesis are numberous and the domain of hematology and hematopathology.
Normal haematopoiesis
Microscopic
One should see three cell lines:[1]
- Erythroid cells.
- Myeloid cells.
- Megakaryocytes.
Images
Nucleated RBCs - high mag. (WC)
www:
Extramedullary haematopoiesis
- Abbreviated EMH.
General
- In adults it is a compensatory mechanism for bone marrow dysfunction.
Cause:
- Any process that disrupts the bone marrow, e.g. fibrous dysplasia.
Locations:[3]
Microscopic
Features:
- Erythroid cells - esp. nucleated red blood cells.
- Myeloid - granulocytes and granulocyte precursors.
- Megakaryocytes - Large cells (50-100 μm) with abundant cytoplasm.
- Make platelets.
Images
Nucleated RBC - high mag. (WC)
www:
See also
References
- ↑ URL: http://emedicine.medscape.com/article/199003-overview. Accessed on: 22 November 2010.
- ↑ URL: http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html. Accessed on: 22 November 2010.
- ↑ URL: http://path.upmc.edu/cases/case283/dx.html. Accessed on: 14 January 2012.