Hepatocyte nuclear factor-1beta

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Hepatocyte nuclear factor-1beta, abbreviated HNF-1beta and HNF-1β, is an immunostain that marks clear cell carcinoma of the ovary.



  • CA-125, RCCma, and CD10 can help distinguish clear cell renal cell carcinoma and Müllerian clear cell tumours.[4]

Occasionally positive



  1. Hanley KZ, Cohen C, Osunkoya AO (February 2017). "Hepatocyte Nuclear Factor-1β Expression in Clear Cell Renal Cell Carcinoma and Urothelial Carcinoma With Clear Cell Features: A Potential Diagnostic Pitfall". Appl. Immunohistochem. Mol. Morphol. 25 (2): 134–138. doi:10.1097/PAI.0000000000000279. PMID 26574638.
  2. Kim M, Joo JW, Lee SJ, Cho YA, Park CK, Cho NH (March 2020). "Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes". Cancers (Basel) 12 (3). doi:10.3390/cancers12030602. PMC 7139472. PMID 32150988. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139472/.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Yang MX, Coates RF, Ambaye A, Gardner JA, Zubarick R, Gao Y, Skelly J, Liu JG, Mino-Kenudson M (2018). "Investigation of HNF-1B as a diagnostic biomarker for pancreatic ductal adenocarcinoma". Biomark Res 6: 25. doi:10.1186/s40364-018-0139-6. PMC 6062876. PMID 30065837. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062876/.
  4. Mentrikoski MJ, Wendroth SM, Wick MR (October 2014). "Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin". Appl Immunohistochem Mol Morphol 22 (9): 635–41. doi:10.1097/PAI.0000000000000004. PMID 25279712.