Flat epithelial atypia

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Flat epithelial atypia, abbreviated FEA, is a benign breast lesion that is associated with an increased risk of subsequent breast cancer.

General

Epidemiology:

  • Associated with ADH & DCIS; may represent a non-obligate precursor lesion of ADH & DCIS.[1]
  • Low risk of progression to invasive malignancy.[2]

Management:

  • Excision.

Microscopic

Features:

  • "Flat" ~ three cells thick.
  • Hypercellular gland -- several layers.
  • Columnar cell morphology.
  • +/-Apical snouts.

DDx:

Images

Molecular

See also

References

  1. Lerwill, MF. (Apr 2008). "Flat epithelial atypia of the breast.". Arch Pathol Lab Med 132 (4): 615-21. doi:10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2. PMID 18384213.
  2. Schnitt, SJ. (2003). "The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.". Breast Cancer Res 5 (5): 263-8. doi:10.1186/bcr625. PMID 12927037.