Flat epithelial atypia
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Flat epithelial atypia, abbreviated FEA, is a benign breast lesion that is associated with an increased risk of subsequent breast cancer.
General
Epidemiology:
- Associated with ADH & DCIS; may represent a non-obligate precursor lesion of ADH & DCIS.[1]
- Low risk of progression to invasive malignancy.[2]
Management:
- Excision.
Microscopic
Features:
- "Flat" ~ three cells thick.
- Hypercellular gland -- several layers.
- Columnar cell morphology.
- +/-Apical snouts.
DDx:
- Columnar cell change.
- Columnar cell hyperplasia.
- ADH.
- Flat DCIS (clinging carcinoma).
- Apocrine cyst - granular cytoplasm.
- Tubular carcinoma - should be considered due to the association.
Images
Breast - Flat Atypia (SKB)
_PA.JPG)
Molecular
- Loss of 16q.
- Not used for diagnosis.
See also
References
- ↑ Lerwill, MF. (Apr 2008). "Flat epithelial atypia of the breast.". Arch Pathol Lab Med 132 (4): 615-21. doi:10.1043/1543-2165(2008)132[615:FEAOTB]2.0.CO;2. PMID 18384213.
- ↑ Schnitt, SJ. (2003). "The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.". Breast Cancer Res 5 (5): 263-8. doi:10.1186/bcr625. PMID 12927037.