Emperipolesis is an intact cell within another cell. The term is derived from em (inside), peri (around), and polemai (is wander about).
- Nonspecific finding seen in a number of conditions.
It is seen in:
- Intact cell (e.g. lymphocyte, neutrophil) within a macrophage.
- Engulfed cell usually has a halo around it.
- Cell overlap.
Emperipolesis in Rosai-Dorfman disease. S100 immunostain.
Megakaryocyte containing a neutrophil. May-Grünwald Giemsa stain.