Digital papillary adenocarcinoma
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| Digital papillary adenocarcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | aggressive digital papillary adenocarcinoma |
| LM DDx | basal cell carcinoma, other basaloid tumours |
| IHC | pankeratin +ve, CEA +ve (edge of ducts/spaces), EMA +ve (edge of ducts/spaces), S-100 +ve (luminal cells), SMA +ve (outer myoepithelial cell layer), p63 +ve (outer myoepithelial cell layer) |
| Site | skin - digits (fingers or toes) |
|
| |
| Prevalence | very rare |
| Prognosis | aggressive |
| Treatment | ampuation |
Digital papillary adenocarcinoma (abbreviated DPA), also aggressive digital papillary adenocarcinoma (abbreviated ADPA), is a rare malignant skin tumour.[1]
General
- Very rare.
- Aggressive - amputation is typically recommended.[2]
- Typically males 50-80 years old.
- May be seen in adolescents.[3]
Gross
- Distal end of a finger or toe.
- Usually fingers.[1]
Microscopic
Features:
- Papillary projections - very common, not required.
- Tubular structures.
- Basaloid cells usually with mild-to-moderate atypia.
- Fibrous stroma.[4]
DDx:
- Basal cell carcinoma.
- Papillary eccrine adenoma.
- Other basaloid tumours.
Images
IHC
Features:[1]
- Pankeratin +ve.
- CEA +ve (edge of ducts/spaces).
- EMA +ve (edge of ducts/spaces).
- S-100 +ve (luminal cells).
- SMA +ve (outer myoepithelial cell layer).
- p63 +ve (outer myoepithelial cell layer).
See also
References
- ↑ 1.0 1.1 1.2 Suchak R, Wang WL, Prieto VG, et al. (December 2012). "Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations". Am. J. Surg. Pathol. 36 (12): 1883–91. doi:10.1097/PAS.0b013e31826320ec. PMID 23026931.
- ↑ Hsu HC, Ho CY, Chen CH, Yang CH, Hong HS, Chuang YH (March 2010). "Aggressive digital papillary adenocarcinoma: a review". Clin. Exp. Dermatol. 35 (2): 113–9. doi:10.1111/j.1365-2230.2009.03490.x. PMID 19874325.
- ↑ Frey J, Shimek C, Woodmansee C, et al. (February 2009). "Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature". J. Am. Acad. Dermatol. 60 (2): 331–9. doi:10.1016/j.jaad.2008.07.038. PMID 18819728.
- ↑ 4.0 4.1 Jefferson J, Thompson C, Rich P (February 2014). "A slowly enlarging mass on the finger". Dermatol. Online J. 20 (2). PMID 24612571.
- ↑ Rastrelli M, Soteldo J, Vitali GC, et al. (2011). "Aggressive digital papillary adenocarcinoma". Indian J Cancer 48 (1): 126–7. doi:10.4103/0019-509X.76641. PMID 21330762.
- ↑ Gole GN, Tati SY, Deshpande AK, Gole SG (June 2011). "Aggressive Digital Papillary Adenocarcinoma in a Young Female-a Rare Presentation". J Hand Microsurg 3 (1): 31–3. doi:10.1007/s12593-010-0028-1. PMC 3094519. PMID 22654416. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094519/.