DNA repair genes
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DNA repair genes fix broken DNA. Failure of DNA repair can lead to cancer.
There is a long and growing list of DNA repair genes.[1]
Examples
| Gene | Syndrome | Tumours |
|---|---|---|
| BRCA1 | familial breast and ovarian cancer | breast, ovary, prostate, pancreas, male breast, fallopian tube |
| BRCA2 | familial breast and ovarian cancer 2 | breast, ovary, prostate, pancreas, stomach, male breast, melanoma, stomach, biliary, pharynx |
| MSH2 | Lynch syndrome | colorectal, endometrial, gastric, pancreas, urothelial, biliary |
References
- ↑ Wood, RD.; Mitchell, M.; Sgouros, J.; Lindahl, T. (Feb 2001). "Human DNA repair genes.". Science 291 (5507): 1284-9. doi:10.1126/science.1056154. PMID 11181991.