Cystitis cystica

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Cystitis cystica
Diagnosis in short

Cystitis cystica. H&E stain.

LM nests of urothelium within the lamina propria with cyst formation, i.e. lumens are present; no nuclear atypia
LM DDx nested urothelial carcinoma, cystitis cystica et glandularis, inverted urothelial papilloma
Site urinary bladder - see urothelium

Prevalence common
Prognosis benign
Clin. DDx urothelial carcinoma

Cystitis cystica is a common inflammatory process of the urinary bladder with cyst formation.

General

Microscopic

Features:[4]

  • Nests of urothelium within the lamina propria with cyst formation, i.e. lumens are present.

Note:

  • Nests should not extend into the muscularis propria.

DDx:

Images

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URINARY BLADDER, BIOPSY:
- CYSTITIS CYSTICA.
- NEGATIVE FOR MALIGNANCY.
URINARY BLADDER, TRANSURETHRAL RESECTION:
- CYSTITIS CYSTICA ET GLANDULARIS, FOCALLY WITH LARGE THIN-WALLED CYSTS.
- PROMINENT BENIGN DILATED SUPERFICIAL BLOOD VESSELS, FOCAL.
- NEGATIVE FOR MALIGNANCY.
URINARY BLADDER (TRIGONE), TRANSURETHRAL BIOPSY:
- SMALL POLYPOID FRAGMENT OF UROTHELIUM CONSISTENT WITH CYSTITIS CYSTICA.
- NO SQUAMOUS METAPLASTIC CHANGE IDENTIFIED.
- NO EVIDENCE OF MALIGNANCY.

Micro

The sections show a small fragment of urothelial mucosa with small urothelial nests that are focally cystic. The nests are well-circumscribed and approximately of equal size. Adjacent to the nests is a small cluster of bland appearing lymphocytes.

No exophytic component is identified. No papillary structures are apparent. The cytomorphology of the urothelium is bland and no mitotic activity is readily apparent.

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 304. ISBN 978-0781765275.
  2. Rothschild, JG.; Wu, G. (2011). "Ureteritis cystica: a radiologic pathologic correlation.". J Clin Imaging Sci 1: 23. doi:10.4103/2156-7514.80375. PMID 21966620.
  3. Conces, MR.; Williamson, SR.; Montironi, R.; Lopez-Beltran, A.; Scarpelli, M.; Cheng, L. (Sep 2012). "Urethral caruncle: clinicopathologic features of 41 cases.". Hum Pathol 43 (9): 1400-4. doi:10.1016/j.humpath.2011.10.015. PMID 22397870.
  4. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1028. ISBN 0-7216-0187-1.
  5. Wasco, MJ.; Daignault, S.; Bradley, D.; Shah, RB. (Feb 2010). "Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases.". Hum Pathol 41 (2): 163-71. doi:10.1016/j.humpath.2009.07.015. PMID 19800100.