Cribriform adenocarcinoma of the minor salivary gland

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Cribriform adenocarcinoma of the minor salivary gland
Diagnosis in short

Cribriform adenocarcinoma of the minor salivary gland. H&E stain.

Synonyms cribriform adenocarcinoma of the tongue

LM cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium
LM DDx polymorphous low grade adenocarcinoma, papillary thyroid carcinoma
IHC CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve
Site head and neck - usually tongue

Prevalence very rare
Prognosis good
Clin. DDx other salivary gland tumours
Treatment excision

Cribriform adenocarcinoma of the minor salivary gland, abbreviated CAMSG, is a rare malignancy of the salivary gland, typically of the tongue.[1]

It is also known as cribriform adenocarcinoma of the tongue, abbreviated CAT.

General

  • Rare - small case series and case reports.
  • Typically tongue - first described there.[2]
  • Good prognosis[1] - on limited data.

Microscopic

Features:

DDx:

Images

www

IHC

Features:[1]

  • AE1/AE3 +ve (12/12 cases).
  • CAM5.2 +ve (12/12 cases).
  • CK7 +ve (12/12 cases).
  • CK8 +ve (12/12 cases).
  • CK18 +ve (12/12 cases).
  • S-100 +ve (12/12 cases).
  • Vimentin +ve (12/12 cases).
  • CD117 -ve/+ve (5+ve/12 cases).

Molecular

  • Rearrangement of the PRKD genes (PRKD1, PRKD2, PRKD3).[4]

See also

Referencess

  1. 1.0 1.1 1.2 1.3 1.4 Skalova, A.; Sima, R.; Kaspirkova-Nemcova, J.; Simpson, RH.; Elmberger, G.; Leivo, I.; Di Palma, S.; Jirasek, T. et al. (Aug 2011). "Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity.". Am J Surg Pathol 35 (8): 1168-76. doi:10.1097/PAS.0b013e31821e1f54. PMID 21716087.
  2. Michal, M.; Skálová, A.; Simpson, RH.; Raslan, WF.; Curík, R.; Leivo, I.; Mukensnábl, P. (Dec 1999). "Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue.". Histopathology 35 (6): 495-501. PMID 10583573.
  3. 3.0 3.1 Michal, M.; Kacerovska, D.; Kazakov, DV. (Jul 2013). "Cribriform adenocarcinoma of the tongue and minor salivary glands: a review.". Head Neck Pathol 7 Suppl 1: S3-11. doi:10.1007/s12105-013-0457-9. PMID 23821209.
  4. Weinreb, I.; Zhang, L.; Tirunagari, LM.; Sung, YS.; Chen, CL.; Perez-Ordonez, B.; Clarke, BA.; Skalova, A. et al. (Oct 2014). "Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.". Genes Chromosomes Cancer 53 (10): 845-56. doi:10.1002/gcc.22195. PMID 24942367.