Cowper gland adenocarcinoma

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Cowper gland adenocarcinoma, also bulbourethral gland adenocarcinoma, is a cancer of the bulbourethral gland. It is very rare.

General

  • Extremely rare - 9 reported cases in 2016.[1]

Microscopic

Features:[2][3]

  • Cribriform ‡ or trabecular or solid pattern.
  • Cytologically bland morphology.

Note:

DDx:

IHC

Features:[2]

  • CK7 +ve.
  • HWCK +ve.
  • PSA -ve.
  • PSAP -ve.
  • SMA -ve.
  • S-100 -ve.

Note: Benign Cowper's glands are described as PSA +ve, PSAP -ve, HMWK +ve.[5]

See also

References

  1. Zhang M, Pettaway C, Vikram R, Tamboli P (December 2016). "Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature". Hum Pathol 58: 138–144. doi:10.1016/j.humpath.2016.07.027. PMID 27554206.
  2. 2.0 2.1 2.2 WHO Classification of Tumours Editorial Board (2022). Urinary and Male Genital Tumours (5th ed.). Lyon: World Health Organization. pp. 187. ISBN 978-9283245124.
  3. Small JD, Albertsen PC, Graydon RJ, Ricci A, Sardella WV (March 1992). "Adenoid cystic carcinoma of Cowper's gland". J Urol 147 (3): 699–701. doi:10.1016/s0022-5347(17)37357-3. PMID 1311394.
  4. Myers CE, Gatalica Z, Spinelli A, Castro M, Linden E, Sartor O, Sargent M (January 2014). "Metastatic Cancer of Cowper's Gland: A Rare Cancer Managed Successfully by Molecular Profiling". Case Rep Oncol 7 (1): 52–7. doi:10.1159/000357972. PMC 3934673. PMID 24575017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934673/.
  5. Cina, SJ.; Silberman, MA.; Kahane, H.; Epstein, JI. (May 1997). "Diagnosis of Cowper's glands on prostate needle biopsy.". Am J Surg Pathol 21 (5): 550-5. PMID 9158679.