Cowper gland adenocarcinoma
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Cowper gland adenocarcinoma, also bulbourethral gland adenocarcinoma, is a cancer of the bulbourethral gland. It is very rare.
General
- Extremely rare - 9 reported cases in 2016.[1]
Microscopic
- Cribriform ‡ or trabecular or solid pattern.
- Cytologically bland morphology.
Note:
- ‡ May have morphology of adenoid cystic carcinoma and have MYB-NFIB fusion.[2][4]
DDx:
IHC
Features:[2]
- CK7 +ve.
- HWCK +ve.
- PSA -ve.
- PSAP -ve.
- SMA -ve.
- S-100 -ve.
Note: Benign Cowper's glands are described as PSA +ve, PSAP -ve, HMWK +ve.[5]
See also
References
- ↑ Zhang M, Pettaway C, Vikram R, Tamboli P (December 2016). "Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature". Hum Pathol 58: 138–144. doi:10.1016/j.humpath.2016.07.027. PMID 27554206.
- ↑ 2.0 2.1 2.2 WHO Classification of Tumours Editorial Board (2022). Urinary and Male Genital Tumours (5th ed.). Lyon: World Health Organization. pp. 187. ISBN 978-9283245124.
- ↑ Small JD, Albertsen PC, Graydon RJ, Ricci A, Sardella WV (March 1992). "Adenoid cystic carcinoma of Cowper's gland". J Urol 147 (3): 699–701. doi:10.1016/s0022-5347(17)37357-3. PMID 1311394.
- ↑ Myers CE, Gatalica Z, Spinelli A, Castro M, Linden E, Sartor O, Sargent M (January 2014). "Metastatic Cancer of Cowper's Gland: A Rare Cancer Managed Successfully by Molecular Profiling". Case Rep Oncol 7 (1): 52–7. doi:10.1159/000357972. PMC 3934673. PMID 24575017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934673/.
- ↑ Cina, SJ.; Silberman, MA.; Kahane, H.; Epstein, JI. (May 1997). "Diagnosis of Cowper's glands on prostate needle biopsy.". Am J Surg Pathol 21 (5): 550-5. PMID 9158679.