Benign lymphoepithelial lesion

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Benign lymphoepithelial lesion, also known as benign lymphoepithelial cyst, is a rare benign lesion of the head and neck.

It should not be confused the lymphoepithelial lesion found in the GI tract.


  • Usually parotid gland.
  • Associated with autoimmune disease, e.g. Sjoegren disease, may not remain benign.[1]
  • May be seen in the context of HIV.[2]



  • Lymphocytes.
  • Ductal epithelial cells.[3]



  • CD20, CD3 -- mixed population.
  • Kappa ~ lambda.

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Right Total Parotid Gland, Excision:
     - Lymphoepithelial lesion/cyst, benign.
     - Benign parotid gland.
     - Two lymph nodes, NEGATIVE for malignancy (0/2).


The sections show a multiloculated cyst with thin walls containing bland lymphoid cells and unremarkable paucicellular fibrotic tissue. The lymphoid component has germinal centre formation. The cyst lining is predominantly a simple thin epithelium. Minimal cytoplasm is present in the cyst lining. Focally, the epithelium is multilayered; however, pseudo-bilayering is absent. No significant atypia is present. Proliferative activity is not apparent.

See also


  1. Goto, TK.; Shimizu, M.; Kobayashi, I.; Chikui, T.; Kanda, S.; Toshitani, K.; Shiratsuchi, Y.; Yoshida, K. (May 2002). "Lymphoepithelial lesion of the parotid gland.". Dentomaxillofac Radiol 31 (3): 198-203. doi:10.1038/sj/dmfr/4600690. PMID 12058269.
  2. Sekikawa Y, Hongo I (September 2017). "HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining". BMJ Case Rep 2017. doi:10.1136/bcr-2017-221869. PMC 5652621. PMID 28963391.
  3. Metwaly, H.; Cheng, J.; Ida-Yonemochi, H.; Ohshiro, K.; Jen, KY.; Liu, AR.; Saku, T. (Jul 2003). "Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion).". Virchows Arch 443 (1): 17-27. doi:10.1007/s00428-003-0824-0. PMID 12761623.