Adenosis of the prostate gland
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| Adenosis of the prostate gland | |
|---|---|
| Diagnosis in short | |
 Adenosis of prostate gland. H&E stain. | |
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| |
| Synonyms | atypical adenomatous hyperplasia |
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| LM | glandular crowding, bland nuclear features (lack prominent nucleoli, lack nuclear enlargement) |
| LM DDx | prostatic adenocarcinoma (esp. foamy gland adenocarcinoma), bulbourethral gland |
| IHC | patchy basal cell markers (e.g. p63 +ve, CK5/6 +ve), AMACR -ve, ERG -ve |
| Gross | not evident |
| Site | prostate gland - transistion zone |
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| |
| Prevalence | common |
| Prognosis | benign |
| Treatment | none |
Adenosis of the prostate gland, also adenosis of the prostate, is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) prostatic adenocarcinoma.[1]
It is also known as atypical adenomatous hyperplasia.[2][3]
General
- May be mistaken for prostatic adenocarcinoma.[4]
- Lesion of the transistion zone of the prostate.[1]
- Not considered a precursor of prostatic adenocarcinoma.[5]
Microscopic
Features:
- Glandular crowding - key feature.
- Glands may be back-to-back.
- Lack of prominent nucleoli.
DDx:
- Adenocarcinoma of the prostate.
- Foamy gland adenocarcinoma - typically has intraluminal crystalloids.
- Bulbourethral gland - at apex of prostate.
- Atypical sclerosing adenosis of the prostate.[6]
Images
Adenosis - very low mag.
Adenosis - low mag.
Adenosis - intermed. mag.
Adenosis - high mag.
Adenosis - intermed. mag.
Adenosis - high mag.
IHC
- CK5/6 +ve. ‡
- p63 +ve. ‡
- AMACR -ve.
- ERG -ve.[5]
Notes:
- ‡ Often patchy - some glands in a group may lack basal cells.
Images
Adenosis - very low mag.
Adenosis - low mag.
Adenosis - intermed. mag.
Adenosis - high mag.
Adenosis - intermed. mag.
Adenosis - high mag.
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- Typically not reported explicitly.
- IHC should be reported if done.
See also
References
- ↑ 1.0 1.1 Gaudin, PB.; Epstein, JI. (Jul 1995). "Adenosis of the prostate. Histologic features in needle biopsy specimens.". Am J Surg Pathol 19 (7): 737-47. PMID 7793471.
- ↑ Molinié, V.; Vadrot, J.; Duchatelle, V.; Balaton, A.; Abbey-Tobby, A.; Baumert, H. (Apr 2012). "[Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)].". Ann Pathol 32 (2): 114-7. doi:10.1016/j.annpat.2012.02.003. PMID 22520603.
- ↑ Humphrey, PA. (Dec 2012). "Atypical adenomatous hyperplasia (adenosis) of the prostate.". J Urol 188 (6): 2371-2. doi:10.1016/j.juro.2012.09.058. PMID 23000851.
- ↑ Epstein, JI. (Jan 2012). "Diagnosis of limited adenocarcinoma of the prostate.". Histopathology 60 (1): 28-40. doi:10.1111/j.1365-2559.2011.03990.x. PMID 22212076.
- ↑ 5.0 5.1 Green, WM.; Hicks, JL.; De Marzo, A.; Illei, PP.; Epstein, JI. (Sep 2013). "Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate.". Hum Pathol 44 (9): 1895-901. doi:10.1016/j.humpath.2013.02.019. PMID 23664537.
- ↑ Cheng, L.; Bostwick, DG. (Apr 2010). "Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma.". Histopathology 56 (5): 627-31. doi:10.1111/j.1365-2559.2010.03525.x. PMID 20459573.