Apocrine metaplasia of the breast
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Apocrine metaplasia of the breast, also apocrine metaplasia, is a benign change in the breast without increased risk of malignancy.
General
- Benign/not significant. Can be considered to be pretty wallpaper in the house of breast pathology.
- Very common in adults.
- Apocrine lesions as a group are usually benign, some pre-neoplastic and some malignant.[1]
Etiology
- Increased number of mitochondria.
- In other body sites this has different names, e.g. Hurthle cell change (thyroid), oncocytic change (kidney).
Gross
- Blue dome cysts.[2]
Microscopic
Features:
- Eosinophilic cytoplasm - key feature.
- Voluminous pink cytoplasm.
- Apocrine snouts may be present.
- Small protrusiona at the apical aspect of the cell (composed of cytoplasm and plasma membrane).
- Central round nucleus
- Prominent nuclear membrane.
- Prominent, often single nucleolus.
- +/-Luminal papillary tufts.[3]
Note:
- Apocrine changes, i.e. cytoplasmic eosinophilia, can appear in malignant tumours; eosinophilia doesn't make something benign.
Images
Case
AM - low mag.
AM - intermed. mag.
AM - high mag.
AM - very high mag.
AM - very high mag.
Others
FCC with apocrine metaplasia (right bottom of image) - high mag. (WC/Nephron).
Breast - Apocrine Change - high power (SKB)
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- Typically not reported.
See also
References
- ↑ Wells, CA.; El-Ayat, GA. (Dec 2007). "Non-operative breast pathology: apocrine lesions.". J Clin Pathol 60 (12): 1313-20. doi:10.1136/jcp.2006.040626. PMID 18042688.
- ↑ Rodrigues, G.; Prabhu, R.; Nair, R.; Thinda, R. (Aug 2011). "A blue-domed cyst of bloodgood.". Eurasian J Med 43 (2): 132. doi:10.5152/eajm.2011.30. PMID 25610180.
- ↑ URL: http://www.breastpathology.info/Benign%20proliferative%20disease.html. Accessed on: May 9, 2016.