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Diagnosis in short

Angiomyofibroblastoma. H&E stain.

LM hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia
LM DDx aggressive angiomyxoma
Gross well-circumscribed
Site female pelvis (vulva), case reports of similar lesion in males

Clinical history slow growing, usu. not painful
Prevalence very rare
Clin. DDx Bartholin cyst, aggressive angiomyxoma

Angiomyofibroblastoma, abbreviated AMF,[1] is rare uncommon soft tissue lesion of the vulva.


  • Uncommon.
  • Similar lesions reported in males.[2][3]


  • Slow growing.
  • Uncommonly recur.
  • Usually painless.

Clinical DDx:




  • Hypercellular zones and hypocellular edematous zones.
  • Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
  • Myxoid stroma - key feature.
  • Small stellate cell/spindle cells without significant nuclear atypia.





  • Desmin +ve.[4]
  • Vimentin +ve.[4]
  • SMA +ve.
  • S-100 -ve.
  • Actin -ve.
  • CD34 -ve.

See also


  1. Cao D, Srodon M, Montgomery EA, Kurman RJ (April 2005). "Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature". Int. J. Gynecol. Pathol. 24 (2): 196–200. PMID 15782077.
  2. 2.0 2.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
  3. Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
  4. 4.0 4.1 4.2 4.3 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
  5. Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.