Acquired cystic disease of the kidney

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Acquired cystic disease of the kidney (abbreviated ACDK), also acquired cystic disease, is a benign change of the kidney seen in chronic renal failure.

Acquired renal cystic disease and acquired cystic renal disease redirect here.

General

  • Thought to arise due to uremia,[1] not specific to the type of renal dialysis, i.e. hemodialysis vs. peritoneal dialysis.
  • Presence of cysts dependent on duration of dialysis:[1]
    • < 3 years ~44%.
    • >4 years ~80%.
    • >10 years ~90%.
  • Associated with renal cell carcinoma - specifically acquired cystic disease-associated renal cell carcinoma.[2]

Microscopic

Features:[3]

  • Cysts - location: cortex and medulla.
    • Lined by simple flattened epithelium.

DDx:

See also

References

  1. 1.0 1.1 Fick GM, Gabow PA (October 1994). "Hereditary and acquired cystic disease of the kidney". Kidney Int. 46 (4): 951–64. PMID 7861721. http://www.nature.com/ki/journal/v46/n4/pdf/ki1994354a.pdf.
  2. Tickoo, SK.; dePeralta-Venturina, MN.; Harik, LR.; Worcester, HD.; Salama, ME.; Young, AN.; Moch, H.; Amin, MB. (Feb 2006). "Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia.". Am J Surg Pathol 30 (2): 141-53. PMID 16434887.
  3. 3.0 3.1 Kessler M, Testevuide P, Aymard B, Huu TC (1991). "Acquired renal cystic disease mimicking adult polycystic kidney disease in a patient undergoing long-term hemodialysis". Am. J. Nephrol. 11 (6): 513–7. PMID 1819219.