Zenker's diverticulum

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Zenker's diverticulum is an outpouching of the mucosa and submucosa at the junction of the pharynx and esophagus.

Zenker's diverticulum
Diagnosis in short

Consistent with Zenker's diverticulum (squamous mucosa). H&E stain.

Synonyms cricopharyngeal diverticulum, pharyngoesophageal diverticulum and hypopharyngeal diverticulum

LM squamous mucosa without nuclear atypia +/- parakeratosis
LM DDx squamous dysplasia of the esophagus, squamous cell carcinoma of the esophagus, squamous cell carcinoma of the head and neck
Site esophagus/pharynx

Clinical history elderly
Symptoms dysphagia
Prognosis benign
Treatment excision

It is also known as cricopharyngeal diverticulum, pharyngoesophageal diverticulum and hypopharyngeal diverticulum.[1]

General

Clinical:[5]

  • Eldery.
  • Dysphagia - difficultly swallowing.
  • May mimic a thyroid nodule.[7]
  • +/-Aspiration of food.

Gross

Images

Microscopic

Features:[7]

DDx:

Images

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Submitted as "Zenker's Diverticulum", Excision:
- Squamous mucosa with parakeratosis, mild chronic inflammation 
  and fibrosis; compatible with Zenker's diverticulum.
- NEGATIVE for dysplasia and NEGATIVE for malignancy. 

Alternate

Submitted as "Zenker's Diverticulum", Excision:
- Squamous mucosa with mild chronic inflammation and reactive 
  changes; compatible with Zenker's diverticulum.
- Benign skeletal muscle.
- NEGATIVE for dysplasia and NEGATIVE for malignancy. 

See also

References

  1. Nuño-Guzmán, CM.; García-Carrasco, D.; Haro, M.; Arróniz-Jáuregui, J.; Corona, JL.; Salcido, M.. "Zenker's Diverticulum: Diagnostic Approach and Surgical Management.". Case Rep Gastroenterol 8 (3): 346-52. doi:10.1159/000369130. PMID 25759630.
  2. Acar, T.; Savaş, R.; Kocaçelebi, K.; Ersöz, G. (Sep 2015). "Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis.". Dis Esophagus. doi:10.1111/dote.12406. PMID 26415863.
  3. Wakita, A.; Motoyama, S.; Sato, Y.; Yoshino, K.; Sasaki, T.; Saito, H.; Minamiya, Y.; Ogawa, J. (2012). "Squamous cell carcinoma in an esophageal diverticulum below the aortic arch.". Int J Surg Case Rep 3 (11): 574-6. doi:10.1016/j.ijscr.2012.07.010. PMID 22940699.
  4. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 7. ISBN 978-0443066573.
  5. 5.0 5.1 Law, R.; Katzka, DA.; Baron, TH. (Nov 2014). "Zenker's Diverticulum.". Clin Gastroenterol Hepatol 12 (11): 1773-82; quiz e111-2. doi:10.1016/j.cgh.2013.09.016. PMID 24055983.
  6. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 6. ISBN 978-0443066573.
  7. 7.0 7.1 Singaporewalla, RM.; Mukherjee, JJ.; Thamboo, TP.; Cheah, WK. (Dec 2011). "Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound.". Head Neck 33 (12): 1800-3. doi:10.1002/hed.21474. PMID 20665743.