Difference between revisions of "Zenker's diverticulum"
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*Benign. | *Benign. | ||
**A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal | last1 = Acar | first1 = T. | last2 = Savaş | first2 = R. | last3 = Kocaçelebi | first3 = K. | last4 = Ersöz | first4 = G. | title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. | journal = Dis Esophagus | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1111/dote.12406 | PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal | last1 = Wakita | first1 = A. | last2 = Motoyama | first2 = S. | last3 = Sato | first3 = Y. | last4 = Yoshino | first4 = K. | last5 = Sasaki | first5 = T. | last6 = Saito | first6 = H. | last7 = Minamiya | first7 = Y. | last8 = Ogawa | first8 = J. | title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. | journal = Int J Surg Case Rep | volume = 3 | issue = 11 | pages = 574-6 | month = | year = 2012 | doi = 10.1016/j.ijscr.2012.07.010 | PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP|7}}</ref> | **A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal | last1 = Acar | first1 = T. | last2 = Savaş | first2 = R. | last3 = Kocaçelebi | first3 = K. | last4 = Ersöz | first4 = G. | title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. | journal = Dis Esophagus | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1111/dote.12406 | PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal | last1 = Wakita | first1 = A. | last2 = Motoyama | first2 = S. | last3 = Sato | first3 = Y. | last4 = Yoshino | first4 = K. | last5 = Sasaki | first5 = T. | last6 = Saito | first6 = H. | last7 = Minamiya | first7 = Y. | last8 = Ogawa | first8 = J. | title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. | journal = Int J Surg Case Rep | volume = 3 | issue = 11 | pages = 574-6 | month = | year = 2012 | doi = 10.1016/j.ijscr.2012.07.010 | PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP|7}}</ref> | ||
* | *Relatively uncommon<ref name=pmid24055983/> - but most common among esophageal diverticula.<ref>{{Ref GLP|6}}</ref> | ||
Clinical:<ref name=pmid24055983>{{Cite journal | last1 = Law | first1 = R. | last2 = Katzka | first2 = DA. | last3 = Baron | first3 = TH. | title = Zenker's Diverticulum. | journal = Clin Gastroenterol Hepatol | volume = 12 | issue = 11 | pages = 1773-82; quiz e111-2 | month = Nov | year = 2014 | doi = 10.1016/j.cgh.2013.09.016 | PMID = 24055983 }}</ref> | Clinical:<ref name=pmid24055983>{{Cite journal | last1 = Law | first1 = R. | last2 = Katzka | first2 = DA. | last3 = Baron | first3 = TH. | title = Zenker's Diverticulum. | journal = Clin Gastroenterol Hepatol | volume = 12 | issue = 11 | pages = 1773-82; quiz e111-2 | month = Nov | year = 2014 | doi = 10.1016/j.cgh.2013.09.016 | PMID = 24055983 }}</ref> | ||
Revision as of 15:55, 9 November 2015
Zenker's diverticulum is an outpouching of the mucosa and submucosa at the junction of the pharynx and esophagus.
It is also known as cricopharyngeal diverticulum, pharyngoesophageal diverticulum and hypopharyngeal diverticulum.[1]
General
- Clinical diagnosis.
- Benign.
- A malignancy (squamous cell carcinoma) may arise from it;[2][3] seen in ~0.3% of cases.[4]
- Relatively uncommon[5] - but most common among esophageal diverticula.[6]
Clinical:[5]
Gross
Images
Zenker's diverticulum. (WC)
Microscopic
Features:[7]
- Squamous mucosa without nuclear atypia +/- parakeratosis.
DDx:
Sign out
Submitted as "Zenker's Diverticulum", Excision: - Squamous mucosa with parakeratosis, mild chronic inflammation and fibrosis; compatible with Zenker's diverticulum. - NEGATIVE for dysplasia and NEGATIVE for malignancy.
Alternate
Submitted as "Zenker's Diverticulum", Excision: - Squamous mucosa with mild chronic inflammation and reactive changes; compatible with Zenker's diverticulum. - Benign skeletal muscle. - NEGATIVE for dysplasia and NEGATIVE for malignancy.
See also
References
- ↑ Nuño-Guzmán, CM.; García-Carrasco, D.; Haro, M.; Arróniz-Jáuregui, J.; Corona, JL.; Salcido, M.. "Zenker's Diverticulum: Diagnostic Approach and Surgical Management.". Case Rep Gastroenterol 8 (3): 346-52. doi:10.1159/000369130. PMID 25759630.
- ↑ Acar, T.; Savaş, R.; Kocaçelebi, K.; Ersöz, G. (Sep 2015). "Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis.". Dis Esophagus. doi:10.1111/dote.12406. PMID 26415863.
- ↑ Wakita, A.; Motoyama, S.; Sato, Y.; Yoshino, K.; Sasaki, T.; Saito, H.; Minamiya, Y.; Ogawa, J. (2012). "Squamous cell carcinoma in an esophageal diverticulum below the aortic arch.". Int J Surg Case Rep 3 (11): 574-6. doi:10.1016/j.ijscr.2012.07.010. PMID 22940699.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 7. ISBN 978-0443066573.
- ↑ 5.0 5.1 Law, R.; Katzka, DA.; Baron, TH. (Nov 2014). "Zenker's Diverticulum.". Clin Gastroenterol Hepatol 12 (11): 1773-82; quiz e111-2. doi:10.1016/j.cgh.2013.09.016. PMID 24055983.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 6. ISBN 978-0443066573.
- ↑ 7.0 7.1 Singaporewalla, RM.; Mukherjee, JJ.; Thamboo, TP.; Cheah, WK. (Dec 2011). "Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound.". Head Neck 33 (12): 1800-3. doi:10.1002/hed.21474. PMID 20665743.