Difference between revisions of "Warthin tumour"

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*May be bilateral ~10% of the time.
*May be bilateral ~10% of the time.
*Classically: male > female -- changing with more women smokers.
*Classically: male > female -- changing with more women smokers.
*Smokers.
*Smokers.<ref>{{Cite journal  | last1 = Chedid | first1 = HM. | last2 = Rapoport | first2 = A. | last3 = Aikawa | first3 = KF. | last4 = Menezes | first4 = Ados S. | last5 = Curioni | first5 = OA. | title = Warthin's tumor of the parotid gland: study of 70 cases. | journal = Rev Col Bras Cir | volume = 38 | issue = 2 | pages = 90-4 | month =  | year =  | doi =  | PMID = 21710045 }}</ref>
*Old - usually 60s, very rarely < 40 years old.
*Old - usually 60s,<ref>{{Cite journal  | last1 = Dăguci | first1 = L. | last2 = Simionescu | first2 = C. | last3 = Stepan | first3 = A. | last4 = Munteanu | first4 = C. | last5 = Dăguci | first5 = C. | last6 = Bătăiosu | first6 = M. | title = Warthin tumor--morphological study of the stromal compartment. | journal = Rom J Morphol Embryol | volume = 52 | issue = 4 | pages = 1319-23 | month =  | year = 2011 | doi =  | PMID = 22203940 }}
</ref> very rarely < 40 years old.


Notes:
Notes:

Revision as of 23:58, 13 July 2013

Warthin tumour
Diagnosis in short

Warthin tumour. H&E stain.

LM papillae with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells), fibrous capsule, cystic space filled with debris, lymphoid stroma
LM DDx lymphoepithelial cyst.
Site salivary gland - parotid gland only

Clinical history strong association of smoking
Prevalence uncommon
Prognosis good, benign
Clin. DDx other salivary gland tumours

Warthin tumour is a relative common benign tumour of the parotid gland. It is also known as papillary cystadenoma lymphomatosum.

General

  • Benign.

Epidemiology:

  • May be multicentric ~ 15% of the time.
  • May be bilateral ~10% of the time.
  • Classically: male > female -- changing with more women smokers.
  • Smokers.[1]
  • Old - usually 60s,[2] very rarely < 40 years old.

Notes:

  • No malignant transformation.
  • Not in submandibular gland.
  • Not in sublingual gland.
  • Not in children.

Gross

  • Motor-oil like fluid.
  • Cystic component larger in larger lesions.
    • Small lesions may be solid.

Image:

Microscopic

Features:

  • Papillae (nipple-shaped structures) with a two rows of pink (eosinophilic) epithelial cells (with cuboidal basal cells and columnar luminal cells) -- key feature.
  • Fibrous capsule - pink & homogenous on H&E stain.
  • Cystic space filled with debris in situ (not necrosis).
  • Lymphoid stroma.

Notes:

  • +/-Squamous differentiation.
  • +/-Goblet cell differentiation.

DDx:

  • Lymphoepithelial cyst.
    • Cyst within a lymph node.

Images

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PAROTID GLAND, RIGHT, EXCISION:
- WARTHIN TUMOUR.

See also

References

  1. Chedid, HM.; Rapoport, A.; Aikawa, KF.; Menezes, Ados S.; Curioni, OA.. "Warthin's tumor of the parotid gland: study of 70 cases.". Rev Col Bras Cir 38 (2): 90-4. PMID 21710045.
  2. Dăguci, L.; Simionescu, C.; Stepan, A.; Munteanu, C.; Dăguci, C.; Bătăiosu, M. (2011). "Warthin tumor--morphological study of the stromal compartment.". Rom J Morphol Embryol 52 (4): 1319-23. PMID 22203940.