Difference between revisions of "Vascular thrombus"

Revision as of 22:04, 5 April 2016

Vascular thrombus is an uncommon pathology specimen that may be from an artery or vein.

Venous thrombus and arterial thrombus redirect here.

General

Uncommonly comes to pathology.

Risk factors - think Virchow's triad:

Stasis, e.g. atrial fibrillation.
Hypercoagulable states, e.g. cancer - see risks factors venous thromboembolism.
Endothelial injury.

Gross

See pulmonary embolism.

Features:

Dull appearance.
Laminations.

Microscopic

Features:

Layers consisting of platelets and fibrin.
- Classically alternating with layers of RBCs - known as Lines of Zahn.^[1]

Note:

Multiple laminations (layers), in general, suggest that clot was formed in a dynamic environment, i.e. in the context of blood flow.

DDx:

Tumour embolus - malignant cells.
Thromboembolus - may require clinical history.
Fat embolism.
Amniotic fluid embolus - in the context of pregnancy/postpartum.
Foreign body.

Images

Laminated thrombus - low mag. (WC)
Laminated thrombus - high mag. (WC)

www

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BLOOD CLOT, LEFT ILIAC ARTERY, THROMBECTOMY:
- THROMBUS.
- NEGATIVE FOR MALIGNANCY.

BLOOD CLOT, LEFT ARM - BRACHIAL ARTERY, THROMBECTOMY/EMBOLECTOMY:
- THROMBUS.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show layers of red blood cells alternating with fibrin and white blood cells (Lines of Zahn).

References

↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 124. ISBN 978-1416031215.

[Ref_PBoD8_124-1] Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 124. ISBN 978-1416031215.

[1]

@@ Line 1: / Line 1: @@
-#redirect [[Ditzels#Vascular_thrombus]]
+'''Vascular thrombus''' is an uncommon [[pathology]] specimen that may be from an artery or vein.
+''Venous thrombus'' and ''arterial thrombus'' redirect here.
+==General==
+*Uncommonly comes to [[pathology]].
+Risk factors - think [[Virchow's triad]]:
+*Stasis, e.g. atrial fibrillation.
+*Hypercoagulable states, e.g. cancer - see ''[[risks factors venous thromboembolism]]''.
+*Endothelial injury.
+===Gross===
+: See ''[[pulmonary embolism]]''.
+Features:
+*Dull appearance.
+*Laminations.
+===Microscopic===
+Features:
+*Layers consisting of platelets and fibrin.
+**Classically alternating with layers of RBCs - known as ''Lines of Zahn''.<ref name=Ref_PBoD8_124>{{Ref PBoD8|124}}</ref>
+Note:
+*Multiple laminations (layers), in general, suggest that clot was formed in a dynamic environment, i.e. in the context of blood flow.
+DDx:
+*Tumour embolus - malignant cells.
+*Thromboembolus - may require [[clinical history]].
+*[[Fat embolism]].
+*Amniotic fluid embolus - in the context of pregnancy/postpartum.
+*Foreign body.
+===Images===
+<gallery>
+Image:Laminations_in_a_thrombus_-_low_mag.jpg | Laminated thrombus - low mag. (WC)
+Image:Laminations_in_a_thrombus_-_high_mag.jpg | Laminated thrombus - high mag. (WC)
+</gallery>
+====www====
+*[http://library.med.utah.edu/WebPath/ATHHTML/ATH031.html Lines of Zahn (utah.edu)].
+*[http://pathhsw5m54.ucsf.edu/case9/image94.html Lines of Zahn (ucsf.edu)].
+==Sign out==
+<pre>
+BLOOD CLOT, LEFT ILIAC ARTERY, THROMBECTOMY:
+- THROMBUS.
+- NEGATIVE FOR MALIGNANCY.
+</pre>
+<pre>
+BLOOD CLOT, LEFT ARM - BRACHIAL ARTERY, THROMBECTOMY/EMBOLECTOMY:
+- THROMBUS.
+- NEGATIVE FOR MALIGNANCY.
+</pre>
+===Micro===
+The sections show layers of red blood cells alternating with fibrin and white blood cells (Lines of Zahn).
+==See also==
+*[[Cardiovascular pathology]].
+*[[Ditzels]].
+==References==
+{{Reflist|1}}
 [[Category:Diagnosis]]
+[[Category:Ditzels]]

Difference between revisions of "Vascular thrombus"

Revision as of 22:04, 5 April 2016

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