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Difference between revisions of "Uterine tumours"
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→Microscopic: more
(→Microscopic: more) |
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*Smooth muscle differentiation - '''key feature'''. | *Smooth muscle differentiation - '''key feature'''. | ||
**Fascicular architecture. | **Fascicular architecture. | ||
***Whorled look at low power. | |||
***Groups of spindle cells cut peripendicular to their long axis adjacent to groups of spindle cells cut in the plane of their long axis. | |||
**May rely on [[IHC]] - if poorly differentiated. | **May rely on [[IHC]] - if poorly differentiated. | ||
*Malignant histomorphologic features - all three required: | *Malignant histomorphologic features - all three required: | ||
*# | *#[[Nuclear pleomorphism]]. | ||
*#[[Necrosis]]. | *#[[Necrosis]]. | ||
*#*Should be patchy/multifocal. | *#*Should be patchy/multifocal. | ||
*#*Zonal necrosis is suggestive of vascular cause. | *#*Zonal necrosis is suggestive of vascular cause and may be a degenerative change. | ||
*#**Zonal necrosis may be seen in (benign) leiomyomas. | |||
*#Mitoses - '''key feature'''. | *#Mitoses - '''key feature'''. | ||
*#*10 mitoses/HPF. | *#*10 mitoses/HPF. | ||