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Difference between revisions of "Uterine tumour resembling an ovarian sex cord stromal tumour"
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Uterine tumour resembling an ovarian sex cord stromal tumour (view source)
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==General== | ==General== | ||
*Super rare. | *Super rare.<ref name=pmid25150955/> | ||
*Typically postmenopausal - mean age ~ 52 years.<ref name=pmid25150955/> | |||
*Usually presentation is [[abnormal uterine bleeding]].<ref name=pmid25150955>{{Cite journal | last1 = Blake | first1 = EA. | last2 = Sheridan | first2 = TB. | last3 = Wang | first3 = KL. | last4 = Takiuchi | first4 = T. | last5 = Kodama | first5 = M. | last6 = Sawada | first6 = K. | last7 = Matsuo | first7 = K. | title = Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 181 | issue = | pages = 163-70 | month = Oct | year = 2014 | doi = 10.1016/j.ejogrb.2014.07.050 | PMID = 25150955 }}</ref> | |||
*Prognosis good if tumour predominantly sex cord-like, i.e. ''Type 2''.<ref name=pmid25150955/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Look like sex cord tumour:<ref> | *Look like sex cord tumour:<ref name=pmid16118629>{{Cite journal | last1 = Irving | first1 = JA. | last2 = Carinelli | first2 = S. | last3 = Prat | first3 = J. | title = Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 17-24 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800475 | PMID = 16118629 | URL = http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html }}</ref> | ||
**May have: anastomosing cords, [[trabeculae]], small nests and/or tubules. | **May have: anastomosing cords, [[trabeculae]], small nests and/or tubules. | ||
Images | Notes: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860562/figure/fig15/ UTROSCT (nih.gov)].<ref>{{Cite journal | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 }} | *May be subdivided into:<ref name=pmid25257516/> | ||
**Type 1 <50% sex cord-component (may be referred to as ''endometrial stromal tumour with sex cord-like elements''<ref name=pmid25150955/>). | |||
**Type 2 >50% sex cord-component. | |||
DDx: | |||
*[[Endometrial stromal sarcoma]]. | |||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860562/figure/fig15/ UTROSCT (nih.gov)].<ref name=pmid17347285>{{Cite journal | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 }} | |||
</ref> | </ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230524/figure/Fig1/ UTROSCT (nih.gov)].<ref name=pmid25395990>{{Cite journal | last1 = Hashmi | first1 = AA. | last2 = Faridi | first2 = N. | last3 = Edhi | first3 = MM. | last4 = Khan | first4 = M. | title = Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review. | journal = Int Arch Med | volume = 7 | issue = 1 | pages = 47 | month = | year = 2014 | doi = 10.1186/1755-7682-7-47 | PMID = 25395990 }}</ref> | |||
==IHC== | |||
Features:<ref name=pmid25257516>{{Cite journal | last1 = Bakula-Zalewska | first1 = E. | last2 = Danska-Bidzinska | first2 = A. | last3 = Kowalewska | first3 = M. | last4 = Piascik | first4 = A. | last5 = Nasierowska-Guttmejer | first5 = A. | last6 = Bidzinski | first6 = M. | title = Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 329-32 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.009 | PMID = 25257516 }}</ref> | |||
*Calretinin +ve (sex cord-like component). | |||
*CD10 +ve (stroma). | |||
*PR +ve. | |||
*Inhibin +ve/-ve. | |||
==See also== | ==See also== | ||