Difference between revisions of "Uterine tumour resembling an ovarian sex cord stromal tumour"

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'''Uterine tumour resembling an ovarian sex cord stromal tumour''', abbreviated ''UTROSCT'', is a very rare [[tumour tumour]].
'''Uterine tumour resembling an ovarian sex cord stromal tumour''', abbreviated '''UTROSCT''', is a very rare [[uterine tumour]].


==General==
==General==
*Super rare.
*Super rare.<ref name=pmid25150955/>
*Typically postmenopausal - mean age ~ 52 years.<ref name=pmid25150955/>
*Usually presentation is [[abnormal uterine bleeding]].<ref name=pmid25150955>{{Cite journal  | last1 = Blake | first1 = EA. | last2 = Sheridan | first2 = TB. | last3 = Wang | first3 = KL. | last4 = Takiuchi | first4 = T. | last5 = Kodama | first5 = M. | last6 = Sawada | first6 = K. | last7 = Matsuo | first7 = K. | title = Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 181 | issue =  | pages = 163-70 | month = Oct | year = 2014 | doi = 10.1016/j.ejogrb.2014.07.050 | PMID = 25150955 }}</ref>
*Prognosis good if tumour predominantly sex cord-like, i.e. ''Type 2''.<ref name=pmid25150955/>


==Microscopic==
==Microscopic==
Features:
Features:
*Look like sex cord tumour:<ref>URL: [http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html]. Accessed on: 5 August 2010.</ref>
*Look like sex cord tumour:<ref name=pmid16118629>{{Cite journal  | last1 = Irving | first1 = JA. | last2 = Carinelli | first2 = S. | last3 = Prat | first3 = J. | title = Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 17-24 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800475 | PMID = 16118629 | URL = http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html }}</ref>
**May have: anastomosing cords, [[trabeculae]], small nests and/or tubules.
**May have: anastomosing cords, [[trabeculae]], small nests and/or tubules.


Images:
Notes:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860562/figure/fig15/ UTROSCT (nih.gov)].<ref>{{Cite journal  | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 }}
*May be subdivided into:<ref name=pmid25257516/>
**Type 1 <50% sex cord-component (may be referred to as ''endometrial stromal tumour with sex cord-like elements''<ref name=pmid25150955/>).
**Type 2 >50% sex cord-component.
 
DDx:
*[[Endometrial stromal sarcoma]].
 
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860562/figure/fig15/ UTROSCT (nih.gov)].<ref name=pmid17347285>{{Cite journal  | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 }}
</ref>
</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230524/figure/Fig1/ UTROSCT (nih.gov)].<ref name=pmid25395990>{{Cite journal  | last1 = Hashmi | first1 = AA. | last2 = Faridi | first2 = N. | last3 = Edhi | first3 = MM. | last4 = Khan | first4 = M. | title = Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review. | journal = Int Arch Med | volume = 7 | issue = 1 | pages = 47 | month =  | year = 2014 | doi = 10.1186/1755-7682-7-47 | PMID = 25395990 }}</ref>
==IHC==
Features:<ref name=pmid25257516>{{Cite journal  | last1 = Bakula-Zalewska | first1 = E. | last2 = Danska-Bidzinska | first2 = A. | last3 = Kowalewska | first3 = M. | last4 = Piascik | first4 = A. | last5 = Nasierowska-Guttmejer | first5 = A. | last6 = Bidzinski | first6 = M. | title = Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 329-32 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.009 | PMID = 25257516 }}</ref>
*Calretinin +ve (sex cord-like component).
*CD10 +ve (stroma).
*PR +ve.
*Inhibin +ve/-ve.


==See also==
==See also==
*[[Uterine tumours]].
*[[Uterine tumours]].
*[[Ovarian tumours]].
*[[Ovarian tumours]].
*[[Sex cord-stromal tumours]].


==References==
==References==

Latest revision as of 17:54, 23 February 2015

Uterine tumour resembling an ovarian sex cord stromal tumour, abbreviated UTROSCT, is a very rare uterine tumour.

General

  • Super rare.[1]
  • Typically postmenopausal - mean age ~ 52 years.[1]
  • Usually presentation is abnormal uterine bleeding.[1]
  • Prognosis good if tumour predominantly sex cord-like, i.e. Type 2.[1]

Microscopic

Features:

  • Look like sex cord tumour:[2]
    • May have: anastomosing cords, trabeculae, small nests and/or tubules.

Notes:

  • May be subdivided into:[3]
    • Type 1 <50% sex cord-component (may be referred to as endometrial stromal tumour with sex cord-like elements[1]).
    • Type 2 >50% sex cord-component.

DDx:

Images

IHC

Features:[3]

  • Calretinin +ve (sex cord-like component).
  • CD10 +ve (stroma).
  • PR +ve.
  • Inhibin +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Blake, EA.; Sheridan, TB.; Wang, KL.; Takiuchi, T.; Kodama, M.; Sawada, K.; Matsuo, K. (Oct 2014). "Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature.". Eur J Obstet Gynecol Reprod Biol 181: 163-70. doi:10.1016/j.ejogrb.2014.07.050. PMID 25150955.
  2. ↑ Irving, JA.; Carinelli, S.; Prat, J. (Jan 2006). "Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation.". Mod Pathol 19 (1): 17-24. doi:10.1038/modpathol.3800475. PMID 16118629.
  3. ↑ 3.0 3.1 Bakula-Zalewska, E.; Danska-Bidzinska, A.; Kowalewska, M.; Piascik, A.; Nasierowska-Guttmejer, A.; Bidzinski, M. (Dec 2014). "Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases.". Ann Diagn Pathol 18 (6): 329-32. doi:10.1016/j.anndiagpath.2014.08.009. PMID 25257516.
  4. ↑ Baker, P.; Oliva, E. (Mar 2007). "Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.". J Clin Pathol 60 (3): 235-43. doi:10.1136/jcp.2005.031203. PMID 17347285.
  5. ↑ Hashmi, AA.; Faridi, N.; Edhi, MM.; Khan, M. (2014). "Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.". Int Arch Med 7 (1): 47. doi:10.1186/1755-7682-7-47. PMID 25395990.
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