Difference between revisions of "Urothelial carcinoma in situ"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Urothelial carcinoma in situ -- high mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Urothelial carcinoma in situ. [[H&E stain]].
| Synonyms  = high-grade dysplasia
| Synonyms  = high-grade dysplasia
| Micro      =
| Micro      = nuclear changes (enlargement of nuclei (often 4-5x the size of stromal lymphocytes), nuclear pleomorphism - marked variation in size of nuclei), +/-disordered arrangement/crowding of cells, +/-mitoses, +/-enlarged nucleoli
| Subtypes  =
| Subtypes  =
| LMDDx      = [[urothelial carcinoma]], [[urothelial dysplasia]]
| LMDDx      = [[urothelial carcinoma]], [[urothelial dysplasia]], urothelial atypia of unknown significance
| Stains    =
| Stains    =
| IHC        = CK20 +ve (full thickness), Ki-67 high, p53 +ve, CD44 -ve, CK7 +ve
| IHC        = CK20 +ve (full thickness), Ki-67 high, p53 +ve, CD44 -ve, CK7 +ve
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