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Difference between revisions of "Tumour budding"
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==Microscopic== | ==Microscopic== | ||
Definition | Definition in rectal carcinoma - based on international consensus:<ref name=pmid28548122>{{Cite journal | last1 = Lugli | first1 = A. | last2 = Kirsch | first2 = R. | last3 = Ajioka | first3 = Y. | last4 = Bosman | first4 = F. | last5 = Cathomas | first5 = G. | last6 = Dawson | first6 = H. | last7 = El Zimaity | first7 = H. | last8 = Fléjou | first8 = JF. | last9 = Hansen | first9 = TP. | title = Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. | journal = Mod Pathol | volume = 30 | issue = 9 | pages = 1299-1311 | month = Sep | year = 2017 | doi = 10.1038/modpathol.2017.46 | PMID = 28548122 }}</ref> | ||
*Tumour bud = 1-4 cell(s) -- at the tumour front. | *Tumour bud = 1-4 cell(s) -- at the tumour front. | ||
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Note: | Note: | ||
*Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/> | *Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/> | ||
**Microscopes with a 22 mm eye pieces typically have a 0.2376 mm*mm field area with the 40x objective; thus, three fields is 0.7128 mm*mm. | |||
**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | **Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal | last1 = Ueno | first1 = H. | last2 = Murphy | first2 = J. | last3 = Jass | first3 = JR. | last4 = Mochizuki | first4 = H. | last5 = Talbot | first5 = IC. | title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. | journal = Histopathology | volume = 40 | issue = 2 | pages = 127-32 | month = Feb | year = 2002 | doi = | PMID = 11952856 }}</ref> | ||
*"Tumour buds suspended in pools of mucin should not be counted" as per the consensus.<ref name=pmid28548122/> | |||
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Image: Tumour budding in colorectal carcinoma - very high mag.jpg | Tumour budding in CRC - very high mag. (WC) | Image: Tumour budding in colorectal carcinoma - very high mag.jpg | Tumour budding in CRC - very high mag. (WC) | ||
</gallery> | </gallery> | ||
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<pre> | |||
There are <5 tumour buds/0.785 mm*mm; this tumour has low grade tumour budding. | |||
</pre> | |||
<pre> | |||
There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediate grade tumour budding. | |||
</pre> | |||
<pre> | |||
There are >=10 tumour buds/0.785 mm*mm; this tumour has high grade tumour budding. | |||
</pre> | |||
===Alternate=== | |||
<pre> | |||
The tumour is NEGATIVE for significant tumour budding (<5 buds/0.785 mm*mm). | |||
</pre> | |||
==See also== | ==See also== | ||
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*[[In-transit metastasis]]. | *[[In-transit metastasis]]. | ||
*[[Tumour deposits]]. | *[[Tumour deposits]]. | ||
*[[Worst pattern of invasion]]. | |||
*[[Spread through air spaces]]. | |||
==References== | ==References== | ||