Thyroid transcription factor-1

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Thyroid transcription factor-1
Immunostain in short

TTF-1 staining in lung adenocarcinoma. (WC)
Normal staining pattern nuclear staining
Positive adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining)
Negative squamous cell carcinoma of the lung

Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]

Positive staining

  • Nuclear staining.

Normal tissues


Positive staining

Negative staining


See also


  1. Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
  2. Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.
  3. Mishra, M.; Morgan, V.; Hamati, AK.; Al-Abbadi, M. (Jan 2012). "Carcinoma of unknown primary: check the liver... thanks to TTF-1.". Tenn Med 105 (1): 35-6, 40. PMID 22359993.
  4. Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.
  5. Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.