Difference between revisions of "Thyroid gland"

Thyroid gland (view source)

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 ==Anaplastic thyroid carcinoma==
-===Epidemiology===
+{{Main|Anaplastic thyroid carcinoma}}
-*Very rare.
-*Horrible prognosis.
-*Often presents with obstruction.
-*Typically there is a history of a thyroid mass.
-===Microscopic===
-Features:
-*Cytologically malignant:
-**Huge [[NC ratio]].
-**Mitoses.
-*+/-[[Necrosis]].
-Notes:
-*May have features of other thyroid carcinomas, e.g. psammoma bodies, papillae, nuclear changes of PTC.
-Image: [http://commons.wikimedia.org/wiki/File:Anaplastic_thyroid_carcinoma_low_mag.jpg Anaplastic thyroid carcinoma with a component of papillary thyroid carcinoma (WC)].
-DDx:
-*[[Poorly differentiated carcinoma of the thyroid|Poorly differentiated thyroid carcinoma]].
-*[[Squamous cell carcinoma]].
-*[[Medullary thyroid carcinoma]].
-*Sarcoma.
-===IHC===
-*Keratin (AE1/AE3) +ve.
-*Vimentin +ve, >90%.<ref name=pmid1712540>{{cite journal |author=Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA |title=Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases |journal=Am. J. Clin. Pathol. |volume=96 |issue=1 |pages=15–24 |year=1991 |month=July |pmid=1712540 |doi= |url=}}</ref>
-*Thyroglobulin - rarely +ve (~15%).<ref name=pmid1712540/>
-*CEA -ve, calcitonin -ve; to r/o medullary.
-*p53 +ve.
-*[[TTF-1]] +ve.
 ==Lymphomas of the thyroid==