Difference between revisions of "Talk:P16"
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== More on p16 in oral sites== | == More on p16 in oral sites== | ||
p16 in oral sites usually not HPV driven. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836441/ | *p16 in oral sites usually not HPV driven. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836441/ | ||
== Cutaneous SCC == | |||
*p16 positive in ~ 1/3 cases - https://pubmed.ncbi.nlm.nih.gov/28663082/ | |||
== p16 UCC == | |||
https://pubmed.ncbi.nlm.nih.gov/20164052/ | |||
== p16 +ve H&N SqCC vs Lung Primary == | |||
<pre> | |||
Lung primaries are commonly positive for p16[1]; thus, p16 CANNOT be used to reliably differentiate between p16 positive head and neck cancers and lung cancer. | |||
1. Br J Cancer. 2000 Jan;82(2):374-80. doi: 10.1054/bjoc.1999.0929. https://pubmed.ncbi.nlm.nih.gov/10646891/ | |||
https://doi.org/10.1054/bjoc.1999.0929 | |||
</pre> | |||
Latest revision as of 19:55, 18 December 2022
p16 non-oropharyngeal sites
ENT surgeons may over interpret p16 staining in non-oropharyngeal sites. This disclaimer may be useful:
Note: p16 staining in non-oropharyngeal sites is nonspecific in a diagnostic context.
More on p16 in oral sites
- p16 in oral sites usually not HPV driven. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836441/
Cutaneous SCC
- p16 positive in ~ 1/3 cases - https://pubmed.ncbi.nlm.nih.gov/28663082/
p16 UCC
https://pubmed.ncbi.nlm.nih.gov/20164052/
p16 +ve H&N SqCC vs Lung Primary
Lung primaries are commonly positive for p16[1]; thus, p16 CANNOT be used to reliably differentiate between p16 positive head and neck cancers and lung cancer. 1. Br J Cancer. 2000 Jan;82(2):374-80. doi: 10.1054/bjoc.1999.0929. https://pubmed.ncbi.nlm.nih.gov/10646891/ https://doi.org/10.1054/bjoc.1999.0929