Difference between revisions of "TRK fusions"
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*The TRK genes are tyrosine kinase receptors. | *The TRK genes are tyrosine kinase receptors. | ||
*Multiple fusion partners for each gene. | *Multiple fusion partners for each gene. | ||
*Testing: RNA-based next generation sequencing. | *Testing: RNA-based next generation sequencing or IHC (limited sensitivity).<ref name=pmid28719467>{{Cite journal | last1 = Hechtman | first1 = JF. | last2 = Benayed | first2 = R. | last3 = Hyman | first3 = DM. | last4 = Drilon | first4 = A. | last5 = Zehir | first5 = A. | last6 = Frosina | first6 = D. | last7 = Arcila | first7 = ME. | last8 = Dogan | first8 = S. | last9 = Klimstra | first9 = DS. | title = Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. | journal = Am J Surg Pathol | volume = 41 | issue = 11 | pages = 1547-1551 | month = Nov | year = 2017 | doi = 10.1097/PAS.0000000000000911 | PMID = 28719467 }}</ref> | ||
==Classic associations== | ==Classic associations== | ||
Revision as of 05:50, 11 September 2018
TRK fusions are seen in many solid tumours and have targeted drugs.
General
Genes
- TRK1.
- TRK2.
- TRK3.
Notes:
- The TRK genes are tyrosine kinase receptors.
- Multiple fusion partners for each gene.
- Testing: RNA-based next generation sequencing or IHC (limited sensitivity).[1]
Classic associations
- Mammary analogue secretory carcinoma (MASC) - ETV6-NTRK3.[2]
- Secretory breast carcinoma - ETV6-NTRK3.[3]
Drugs
- Merestinib.
- Larotrectinib.
- Others.
See also
References
- ↑ Hechtman, JF.; Benayed, R.; Hyman, DM.; Drilon, A.; Zehir, A.; Frosina, D.; Arcila, ME.; Dogan, S. et al. (Nov 2017). "Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.". Am J Surg Pathol 41 (11): 1547-1551. doi:10.1097/PAS.0000000000000911. PMID 28719467.
- ↑ Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
- ↑ Vasudev, P.; Onuma, K. (Dec 2011). "Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.". Arch Pathol Lab Med 135 (12): 1606-10. doi:10.5858/arpa.2010-0351-RS. PMID 22129193.