Difference between revisions of "TRK fusions"

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*The TRK genes are tyrosine kinase receptors.
 
*The TRK genes are tyrosine kinase receptors.
 
*Multiple fusion partners for each gene.
 
*Multiple fusion partners for each gene.
 +
*Testing: RNA-based next generation sequencing.
  
 
==Classic associations==
 
==Classic associations==

Revision as of 01:47, 11 September 2018

TRK fusions are seen in many solid tumours and have targeted drugs.

General

Genes

  • TRK1.
  • TRK2.
  • TRK3.

Notes:

  • The TRK genes are tyrosine kinase receptors.
  • Multiple fusion partners for each gene.
  • Testing: RNA-based next generation sequencing.

Classic associations

Drugs

  • Merestinib.
  • Larotrectinib.
  • Others.

See also

References

  1. Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. Vasudev, P.; Onuma, K. (Dec 2011). "Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.". Arch Pathol Lab Med 135 (12): 1606-10. doi:10.5858/arpa.2010-0351-RS. PMID 22129193.