Syphilis

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Syphilis is the infectious disease caused by Treponema pallidum.

General

  • Classically affects the testis before the epididymis.[1]

Microscopic

Features:

  • Plasma cells - key feature.[2]
  • Spirochetes - diagnostic.
  • +/-Granulomas[3] - gumma - in the tertiary phase.[4]


Useful stains:

Image: Dieterle stain - T. pallidum (WC).

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 364. ISBN 978-0781765275.
  2. Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
  3. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 47. ISBN 978-1416054542.
  4. URL: http://pediatrics.aappublications.org/cgi/content/full/104/1/e4. Accessed on: 17 November 2010.