Difference between revisions of "Stomach"

Stomach (view source)

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 ==Gastric dysplasia==
 ===General===
-*Criteria similar to those in adenomatous colonic polyps (see ''Microscopic'').
+*Criteria similar to columnar dysplasia in the [[esophagus]].
-*Divided into:
-**Low grade.
+Divided into:
-**High grade.
+*Low grade.
-***Nuclei no longer stratified.
+*High grade.
 ===Microscopic===
+====Low-grade gastric columnar dysplasia====
 Features:
-*Nuclear changes.
+*Nuclear changes:
 **Nuclear crowding/pseudostratification.
 **Elongation of nuclei (cigar-shaped nuclei).
-*Cytoplasm - hyperchromatic.
+**Nuclear stratification intact; nuclei close to the basement membrane.
-*Mitosis - particularly above the basement membrane.
+*Architecture:
+**Focal irregularities in the glandular contours.
+Negatives:
+*No desmoplasia.
+*No necrosis.
+*No surface maturation.
+====High-grade gastric columnar dysplasia====
+Features:
+*Nuclear changes:
+**Round hyperchromatic nuclei.
+**Loss of normal nuclear stratification.
+*Architecture:
+**Irregularities in the glandular contours.
+**Back-to-back glands.
+**Cribriforming of the glands.
 Images: