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→‎Ménétrier's disease: split out
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==Ménétrier's disease==
==Ménétrier's disease==
*[[AKA]] ''diffuse foveolar cell hyperplasia''.<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>
{{Main|Ménétrier's disease}}
===General===
*Super rare.
*Increased risk of gastric adenocarcinoma.<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>
 
Clinical:<ref name=pmid20926644>{{Cite journal  | last1 = Rich | first1 = A. | last2 = Toro | first2 = TZ. | last3 = Tanksley | first3 = J. | last4 = Fiske | first4 = WH. | last5 = Lind | first5 = CD. | last6 = Ayers | first6 = GD. | last7 = Piessevaux | first7 = H. | last8 = Washington | first8 = MK. | last9 = Coffey | first9 = RJ. | title = Distinguishing Ménétrier's disease from its mimics. | journal = Gut | volume = 59 | issue = 12 | pages = 1617-24 | month = Dec | year = 2010 | doi = 10.1136/gut.2010.220061 | PMID = 20926644 }}</ref>
*Classical: nausea, emesis, abdominal pain and peripheral edema.
**Emesis (intractable) - '''most important'''.
 
Other:
*Gastric mass (may mimic cancer).
*Hypochlorhydria.
*Protein loss (hypoalbuminemia) - leads to peripheral edema.
 
Epidemiology:
*Men > women.
*Adults usually 50s.
*Associated with [[ulcerative colitis]].
 
Treatment:
*EGFR inhibitors.<ref name=pmid18321437>{{Cite journal  | last1 = Toubia | first1 = N. | last2 = Schubert | first2 = ML. | title = Menetrier's Disease. | journal = Curr Treat Options Gastroenterol | volume = 11 | issue = 2 | pages = 103-8 | month = Apr | year = 2008 | doi =  | PMID = 18321437 }}</ref>
*Gastrectomy.
 
===Gross===
*"Bag of worms" appearance - very thick gastric folds.
 
===Microscopic===
Features:<ref name=Ref_PCPBoD8_410>{{Ref PCPBoD8|410}}</ref>
*Foveolar cell hyperplasia - '''key feature'''.
*Decreased parietal cells.
*+/-Inflammation.
 
DDx:
*[[Cronkhite-Canada syndrome]].<ref name="pmid11428328">{{cite journal |author=Junnarkar SP, Sloan JM, Johnston BT, Laird JD, Irwin ST |title=Cronkhite-Canada syndrome |journal=The Ulster medical journal |volume=70 |issue=1 |pages=56–8 |year=2001 |month=May |pmid=11428328 |pmc=2449205 |doi= |url=}}</ref>
*[[Hyperplastic polyp of the stomach]].
 
Images:
*[http://path.upmc.edu/cases/case36.html Ménétrier's disease - crappy images (upmc.edu)].


==Gastric xanthoma==
==Gastric xanthoma==
Michael
48,470

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