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Difference between revisions of "Steatohepatitis"
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*[[Hepatitis C]]. | *[[Hepatitis C]]. | ||
*[[Drug-induced liver disease]]. | *[[Drug-induced liver disease]]. | ||
===Image=== | |||
<gallery> | |||
Image:Steatohepatitis_high_mag.jpg | Steatohepatitis. (WC) | |||
</gallery> | |||
===Grading steatohepatitis=== | ===Grading steatohepatitis=== | ||
Grading inflammation:<ref name=pmid10484010>{{Cite journal | last1 = Brunt | first1 = EM. | last2 = Janney | first2 = CG. | last3 = Di Bisceglie | first3 = AM. | last4 = Neuschwander-Tetri | first4 = BA. | last5 = Bacon | first5 = BR. | title = Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. | journal = Am J Gastroenterol | volume = 94 | issue = 9 | pages = 2467-74 | month = Sep | year = 1999 | doi = 10.1111/j.1572-0241.1999.01377.x | PMID = 10484010 }}</ref> | Grading inflammation:<ref name=pmid10484010>{{Cite journal | last1 = Brunt | first1 = EM. | last2 = Janney | first2 = CG. | last3 = Di Bisceglie | first3 = AM. | last4 = Neuschwander-Tetri | first4 = BA. | last5 = Bacon | first5 = BR. | title = Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. | journal = Am J Gastroenterol | volume = 94 | issue = 9 | pages = 2467-74 | month = Sep | year = 1999 | doi = 10.1111/j.1572-0241.1999.01377.x | PMID = 10484010 }}</ref> | ||
*Grade 1 - steatosis, occasional ballooning degeneration | *Grade 1 - steatosis, [[PMN]]s, occasional ballooning degeneration. ‡ | ||
*Grade 2 - obvious ballooning, obvious PMNs, chronic inflammation. | *Grade 2 - obvious ballooning, obvious PMNs, chronic inflammation. | ||
*Grade 3 - panacinar steatosis. | *Grade 3 - panacinar steatosis. | ||
Note: | |||
*‡ Brunt does ''not'' require ballooning to be present to call ''steatohepatitis''.<ref name=pmid10484010/> Brunt in a later paper (surveying pathologists) suggest that a significant number of pathologist see it as a diagnostic criterion.<ref name=pmid11296695>{{Cite journal | last1 = Brunt | first1 = EM. | title = Nonalcoholic steatohepatitis: definition and pathology. | journal = Semin Liver Dis | volume = 21 | issue = 1 | pages = 3-16 | month = | year = 2001 | doi = | PMID = 11296695 }}</ref> | |||
====Images==== | ====Images==== | ||
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|Necroinflammatory grades Brunt 3, NAH 8. Fibrosis stage 4. Steatosis is pan-acinar (UL). Acinar inflammatory aggregates More than 4 inflammatory aggregates are seen in a 20X field (UR black arrowheads). Many cells show ballooning degeneration, with tufts/flocks of material cytoplasm (LL yellow arrowheads) Trichrome limns regenerative nodules (LR magenta arrowheads). Original oculars UL 4X, UR 20X, LL 40X (higher pixel photograph), LR 10X | |Necroinflammatory grades Brunt 3, NAH 8. Fibrosis stage 4. Steatosis is pan-acinar (UL). Acinar inflammatory aggregates More than 4 inflammatory aggregates are seen in a 20X field (UR black arrowheads). Many cells show ballooning degeneration, with tufts/flocks of material cytoplasm (LL yellow arrowheads) Trichrome limns regenerative nodules (LR magenta arrowheads). Original oculars UL 4X, UR 20X, LL 40X (higher pixel photograph), LR 10X | ||
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==See also== | ==See also== | ||